Combined dose and linear energy transfer predict local control after carbon-ion radiotherapy
High-dose, high-linear-energy-transfer target coverage stratified local control after carbon-ion radiotherapy for adenoid cystic carcinoma.
Latest research
Search the archiveRadiotherapy primes PDL1-targeted radionuclide therapy but splenic uptake limits efficacy
Radiotherapy increased tumor uptake of PDL1-targeted radionuclide therapy, while antibody co-dosing reduced splenic trapping and restored antitumor efficacy in mice.
Convergent 60 keV photons show cell-dependent biological effectiveness
Convergent 60 keV photons matched orthovoltage radiation and showed comparable or greater biological effectiveness than 6 MV photons, depending on cell type.
CyberKnife reduced low-dose exposure in left-sided partial-breast irradiation
CyberKnife improved conformity and reduced cardiac, pulmonary, and low-dose exposure, while noncoplanar linac techniques remained clinically acceptable alternatives.
Cosmesis reporting after radiotherapy for non-melanoma skin cancer remains inconsistent
Most studies used heterogeneous, poorly reproducible cosmetic assessment methods, limiting comparisons between radiotherapy techniques and supporting development of a validated standard.
Knowledge-based prostate planning transfers across fractionation regimens with comparable plan quality
A conventional-fractionation model produced clinically acceptable moderately hypofractionated prostate plans, with comparable overall quality and slightly reduced target homogeneity.
Commercial lung phantom density errors can reduce target coverage by 3%
Lot-to-lot density variation in lung-equivalent inserts reduced planning target volume coverage by up to 3%, exceeding the stated clinical tolerance.
Low monitor unit deliveries show pulse-limited variability on a modern linear accelerator
Discrete pulse counts limited fractional monitor unit precision, particularly for high-dose-per-pulse flattening filter-free beams.
Ultrahigh dose-rate protons reduce hydrogen peroxide yield in water
Hydrogen peroxide production decreased as proton dose rate increased, with Geant4-DNA simulations reproducing the oxygen-dependent experimental trend.
Monocular surface imaging enables real-time breast dose reconstruction
Patient-specific surface imaging reconstructed breast radiotherapy dose with a 93.8% gamma passing rate and 42-millisecond latency without additional imaging radiation.
Reference beam data may streamline commissioning but cannot replace local validation
Reference datasets can support linear accelerator beam modelling, but machine-specific measurements remain essential for small fields, complex delivery, and long-term verification.
Neutron background limits prompt-gamma range verification in carbon-ion therapy
Prompt-gamma profiles tracked beam range, but stronger neutron backgrounds reduced retrieval precision for carbon ions under clinically relevant conditions.
Machine-specific timing model improves synchrotron proton spot delivery prediction
Measured multi-energy extraction characteristics enabled accurate delivery-time prediction across 605 clinical proton fields, supporting more reliable interplay simulations.
Dose de-escalation improved patient-reported outcomes in early p16-positive oropharyngeal cancer
Reducing radiotherapy from 70 Gy to 60 Gy was associated with better one-year swallowing outcomes and lower acute toxicity in selected patients.
Prolonged pembrolizumab was associated with longer survival after chemoradiation in non-small cell lung cancer
Longer pembrolizumab exposure after chemoradiation was associated with lower mortality, but immortal time bias prevents causal interpretation.