Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.
Tag
4DCT
Diaphragm motion was less reliable than fiducials for markerless tumor tracking
Tumor–diaphragm geometry varied by approximately 4.5 mm during breathing, substantially more than tumor–fiducial relationships.
4DCT ventilation accurately predicted lung function after cancer resection
4DCT ventilation predicted postoperative FEV1, FVC, and DLCO with concordance coefficients of 0.88–0.91 in the LIME trial.
Early ventilation changes predicted end-of-treatment lung function after radiotherapy
Early-treatment ventilation direction persisted to treatment completion in most photon- and proton-treated patients, with the prediction model explaining 89% of variation.
Abdominal airbag matched plate compression but increased lateral setup error
Airbag compression reduced upper-abdominal respiratory motion comparably to a rigid plate but produced larger left–right setup errors.
Respiratory motion remained small during postoperative whole-breast radiotherapy.
Mean breast target displacement was below 1.3 mm in every direction, with calculated respiratory margins of approximately 1 mm.