Early PSA-density kinetics after prostate SABR identified patients at high recurrence risk
Combining ISUP grade with 3–6-month PSA-density kinetics separated seven-year biochemical control at 93.5% versus 53.4% after SABR without ADT.
Tag
biomarker
Extensive coronary calcification on breast RT planning CT predicted ischemic heart disease
All six ischemic events occurred in patients with extensive coronary calcification on breast RT simulation CT, versus none with absent or mild calcification.
Interim CT shrinkage and FDG-PET uptake predicted head and neck outcomes
Low CT tumour shrinkage strongly predicted poorer locoregional control, while high interim FDG-PET uptake predicted both poorer control and survival.
Pan-cancer gene expression predicted progression after radiotherapy across five cancer types
Leave-one-cancer-type-out genomic scores remained associated with progression in five of eight cancers, with the largest performance gain in cervical cancer.
Prostate radiotherapy biomarker review found timing more limiting than assay choice
None of four selected blood-biomarker domains currently supports treatment personalization, and sampling schedules frequently failed to match expected biological kinetics.
Skin microbiome signatures were associated with moderate-to-severe breast radiodermatitis
Clostridium, Anaerococcus US436 and Granulicatella elegans were associated with moderate-to-severe acute dermatitis during breast radiotherapy.
T1 relaxation mapping identified complete rectal cancer response at six weeks
Quantitative T1 relaxation time distinguished complete from incomplete rectal cancer response six weeks after neoadjuvant treatment with an area under the curve of 0.94.
Circadian disruption may modify radiation-induced acute myeloid leukaemia risk
Circadian dysregulation could impair DNA repair and haematopoietic control after radiation exposure, but direct evidence linking it to acute myeloid leukaemia is lacking.
Lower microvascular health predicted acute radiotherapy toxicity across three cancer cohorts
Lower pretreatment microvascular health was associated with more acute toxicity overall, while disease-specific performance was strongest in breast cancer.
FDG-PET and multiparametric MRI did not reliably predict pCR in esophageal cancer
Combined FDG-PET and multiparametric MRI achieved only modest pCR prediction after neoadjuvant chemoradiotherapy, with a cross-validated AUC of 0.65.
Timing shaped radiotherapy-immunotherapy synergy across mechanisms
This systematic review found that optimal radiotherapy-immunotherapy sequencing depends on the immune mechanism being targeted.
Hydrogen gas inhalation showed exploratory metabolic and toxicity signals during head and neck chemoradiotherapy
Adjunctive hydrogen gas inhalation was associated with numerically fewer moderate toxicities and exploratory serum metabolomic changes during head and neck chemoradiotherapy.
Photon-counting computed tomography estimated physical density with 5.5% phantom error
Photon-counting computed tomography generated effective atomic number and physical density images directly from virtual monoenergetic images.
High lactate dehydrogenase-5 and low lymphocyte infiltration identified higher relapse risk after prostate radiotherapy
Combined high lactate dehydrogenase-5 expression and low tumor-infiltrating lymphocyte density independently identified higher biochemical relapse risk after prostate radiotherapy.