Prophylactic dexamethasone reduced pain flare after radiotherapy for bone metastases
Across six randomized studies, prophylactic corticosteroids reduced radiation-induced pain-flare risk by 37%, although regimens and safety reporting varied.
Tag
bone-metastases
Bone metastasis trials need treatment-intent endpoints beyond pain response
Pain should remain central for symptomatic disease, but prevention, function, local control and skeletal events require separate standardized endpoints.
Machine learning stratified survival after palliative radiotherapy for bone metastases
A decision tree model identified interleukin-8, hemoglobin, and lymphocyte count as key survival predictors after palliative radiotherapy.
Single-fraction radiotherapy matched multifraction treatment for malignant bone tumor pain
Single-fraction external beam radiotherapy provided similar pain relief to multifraction treatment in this meta-analysis of malignant bone tumor pain.
Simulation-free single-fraction radiotherapy was feasible for non-spine metastases
Diagnostic computed tomography-based single-fraction radiotherapy was feasible for selected non-spine palliative metastases, with no grade 3 or higher acute toxicity.
Single-fraction ultrahigh dose-rate proton therapy showed early safety in thoracic metastases
Single-fraction proton treatment produced pain responses without grade 2 or higher related toxicity in 10 patients with thoracic bone metastases.