Bone metastasis trials need treatment-intent endpoints beyond pain response
Pain should remain central for symptomatic disease, but prevention, function, local control and skeletal events require separate standardized endpoints.
Tag
bone-metastases
Machine learning stratified survival after palliative radiotherapy for bone metastases
A decision tree model identified interleukin-8, hemoglobin, and lymphocyte count as key survival predictors after palliative radiotherapy.
Single-fraction radiotherapy matched multifraction treatment for malignant bone tumor pain
Single-fraction external beam radiotherapy provided similar pain relief to multifraction treatment in this meta-analysis of malignant bone tumor pain.
Simulation-free single-fraction radiotherapy was feasible for non-spine metastases
Diagnostic computed tomography-based single-fraction radiotherapy was feasible for selected non-spine palliative metastases, with no grade 3 or higher acute toxicity.
Single-fraction ultrahigh dose-rate proton therapy showed early safety in thoracic metastases
Single-fraction proton treatment produced pain responses without grade 2 or higher related toxicity in 10 patients with thoracic bone metastases.