Knowledge-based breast VMAT achieved low heart doses and no grade 3 toxicity
A standardized knowledge-based VMAT workflow achieved high target coverage, low cardiopulmonary doses and no grade 3 acute toxicity in 484 patients.
Tag
Breast
Skin microbiome signatures were associated with moderate-to-severe breast radiodermatitis
Clostridium, Anaerococcus US436 and Granulicatella elegans were associated with moderate-to-severe acute dermatitis during breast radiotherapy.
Five-fraction whole-breast irradiation showed low short-term toxicity across 28 Italian centres
Whole-breast irradiation with 26 Gy in five fractions produced mainly grade 1 toxicity in 2,036 patients, including those receiving a boost.
Mean lung dose strongly predicted pneumonitis after adjuvant breast radiotherapy
A mean lung dose threshold of 12.70 grays strongly separated patients who developed radiation pneumonitis after adjuvant breast radiotherapy.
Twice-weekly 28 Gy whole-breast irradiation showed low toxicity in early breast cancer
Twice-weekly 28 Gy in 5 fractions produced no grade 3 or higher toxicity and 98.8% excellent-to-good cosmesis at 1 year.
NEOTRAC shortened treatment duration without improving pCR in HER2-positive inoperable breast cancer
Concurrent neoadjuvant radiotherapy shortened treatment duration but did not improve pathological complete response or survival.
Thermo-optical surface guidance supported breast deep inspiration breath-hold radiotherapy setup
Thermo-optical surface monitoring with X-ray correction kept breast deep inspiration breath-hold setup errors within clinical tolerance.
Higher left anterior descending coronary artery dose was associated with cardiac events after breast radiotherapy
A maximum left anterior descending coronary artery dose of at least 12 Gy was independently associated with higher long-term cardiac risk.
Surface scans showed modest average but substantial individual breast deformation during radiotherapy
Mean treated-breast displacement was 1.6 mm, with larger patient-specific changes near treatment completion and during follow-up.
High-dose left anterior descending artery exposure was associated with cardiac events after breast radiotherapy
A 40 Gy equivalent dose to at least 18% of the left anterior descending artery was associated with more than twofold risk of cardiac events.
CyberKnife reduced low-dose exposure in left-sided partial-breast irradiation
CyberKnife improved conformity and reduced cardiac, pulmonary, and low-dose exposure, while noncoplanar linac techniques remained clinically acceptable alternatives.
Monocular surface imaging enables real-time breast dose reconstruction
Patient-specific surface imaging reconstructed breast radiotherapy dose with a 93.8% gamma passing rate and 42-millisecond latency without additional imaging radiation.
FLASH radiotherapy reduced hepatic injury in a murine breast cancer model
FLASH radiotherapy preserved hepatic structure and metabolic homeostasis while maintaining tumor control in a preclinical breast cancer model.
Skin-constrained intensity-modulated proton therapy matches photon postmastectomy radiotherapy for acute dermatitis
Skin-constrained intensity-modulated proton therapy produced acute dermatitis rates comparable with photon postmastectomy radiotherapy (grade ≥2: 47% vs 48%).
Proton reirradiation achieves high locoregional control in recurrent breast cancer
Pencil-beam proton reirradiation for locoregional breast cancer recurrence achieved 95% three-year overall survival, with severe toxicity uncommon despite a 21% rib-fracture rate.