Carbon ions produced more persistent tumor damage but hypoxic cells showed late rebound
Carbon ions prolonged tumor-cell damage while chronic hypoxia supported late proliferative and macrophage rebound in rat prostate tumors.
Tag
carbon-ion
Severe pneumonitis developed after carbon-ion RT following nivolumab in lung cancer
Life-threatening bilateral pneumonitis with concurrent Pneumocystis infection developed three days after carbon-ion RT in a patient previously treated with nivolumab.
Multi-RBE LET optimization increased target LET by 29% in sacral chordoma
Multi-RBE carbon-ion optimization increased near-minimum GTV LET by 29.2% while maintaining conventional dose coverage and interfraction robustness.
Robust optimization minimized lung-dose trade-offs in carbon-ion planning for stage I NSCLC
Robust optimization improved target coverage with less lung-dose penalty than margin expansion, while density override was particularly useful for solid tumors.
More hypofractionated carbon-ion therapy increased sacral fractures without improving survival
Carbon-ion schedules produced similar tumour outcomes, but sacral insufficiency fractures occurred in 47% versus 24% with 4 Gy(RBE) fractions.
Carbon-ion Gy(RBE) values are not directly interchangeable between planning systems
Different carbon-ion RBE models can assign substantially different biological doses to the same absorbed-dose distribution, requiring context-specific translation.
Transformer dose engine achieved near-Monte Carlo accuracy for carbon ion therapy
The Transformer calculated carbon-ion pencil-beam doses in 14 milliseconds with 98.0% gamma agreement at stringent 1%/1 mm criteria.
ATR inhibition enhanced cytotoxic and immunogenic radiation effects in pancreatic cancer cells
ATR inhibition increased radiation-induced cell killing and inflammatory signalling in KRAS wild-type pancreatic cancer cells, with weaker immunogenic effects in KRAS-mutated cells.
Carbon ions triggered distinct cell-cycle and chromatin transcriptional responses
At equal physical dose, carbon ions produced transcriptional changes distinct from X-rays, including stronger suppression of mitotic and chromatin-regulatory programmes.
Upright carbon ion plans matched supine dosimetry for prostate cancer
Upright carbon ion treatment plans achieved target coverage, organ sparing and simulated robustness comparable with conventional supine plans.
Carbon ion re-irradiation showed feasible salvage outcomes in recurrent pelvic sarcoma
High-dose carbon ion re-irradiation achieved 83.1% 3-year survival with no grade 4 toxicity in recurrent pelvic sarcoma.
Carbon ion radiotherapy yielded 82.9% two-year locoregional control in stage III non-small cell lung cancer
Carbon ion radiotherapy achieved 82.9% two-year locoregional control, while combined immunotherapy was associated with longer overall survival.
Combined dose and linear energy transfer predict local control after carbon-ion radiotherapy
High-dose, high-linear-energy-transfer target coverage stratified local control after carbon-ion radiotherapy for adenoid cystic carcinoma.
Neutron background limits prompt-gamma range verification in carbon-ion therapy
Prompt-gamma profiles tracked beam range, but stronger neutron backgrounds reduced retrieval precision for carbon ions under clinically relevant conditions.