Cardiac dose patterns and early ECG changes differed by breast cancer laterality
Left-sided breast IMRT was linked to more repolarization changes, while right-sided treatment produced predominantly rhythm abnormalities.
Tag
cardiac-toxicity
Heart-base optimization substantially reduced cardiac substructure dose in distal esophageal RT
Heart-base-optimized IMRT/VMAT reduced cardiac avoidance area mean dose by about 6 Gy without compromising target coverage.
Sinoatrial node dose was linked to early ECG abnormalities after breast IMRT
Higher sinoatrial node low-dose exposure independently tracked with new ECG abnormalities after postoperative breast IMRT in this exploratory retrospective cohort.
Bayesian heart-dose constraints improved cardiac risk selection in NSCLC
Personalized Bayesian heart-dose limits improved identification of NSCLC patients at low risk of treatment-related cardiac troponin elevation.
Whole-heart dose concealed high cardiac substructure exposure in left-sided lung radiotherapy
Despite a mean whole-heart dose below 9 Gy, eleven cardiac substructures averaged above 10 Gy, and targeted replanning substantially reduced coronary exposure.
Atrial fibrillation affected 7.6% after thoracic radiotherapy in pooled analysis
Reported atrial fibrillation occurred in 7.6% after thoracic radiotherapy when cohorts with substantial perioperative confounding were excluded.
Cardiac avoidance area dose was associated with survival after oesophageal radiotherapy
Maximum cardiac avoidance area dose below 43.5 Gy was associated with longer median survival after curative-intent oesophageal radiotherapy.
Cardiovascular events affected 59% after definitive lung cancer chemoradiotherapy
Cardiovascular events occurred in 59% after definitive lung chemoradiotherapy, while higher heart V20 and V30 independently tracked with greater event risk.
Longitudinal muscle loss and myocardial remodeling tracked worse survival after non-small cell lung cancer radiotherapy
Skeletal muscle loss and substantial left ventricular mass changes on follow-up imaging were strongly associated with poorer survival after curative radiotherapy.
AI-derived LAD dose reproduced survival stratification in RTOG 0617
Automated LAD contours reproduced the association between coronary dose and survival in 460 stage III NSCLC patients, although performance varied by model.
Cardiac-dose model validated non-cancer death risk in one lung SBRT cohort
The model calibrated well only when non-cancer death was defined consistently; an overall-survival version validated in both external cohorts.
Different factors predicted cardiac-event subtypes after hypofractionated breast radiotherapy
Planning-CT calcification and age predicted atherosclerotic events, while anthracyclines and respiratory toxicity predicted other cardiac complications.
Probabilistic coronary habitats enabled artery-focused cardiac sparing without angiography
Automatically predicted coronary habitats captured most arteries and enabled substantial dose reductions in three retrospectively replanned thoracic cases.
Cardiac toxicity occurred in 8% after central and ultracentral lung SBRT
Symptomatic grade ≥2 cardiac toxicity occurred in 8% after central or ultracentral lung SBRT, typically developing more than one year after treatment.
Higher left anterior descending coronary artery dose was associated with cardiac events after breast radiotherapy
A maximum left anterior descending coronary artery dose of at least 12 Gy was independently associated with higher long-term cardiac risk.