CBCT adaptive RT is increasingly automated, but clinical decision-making still needs human oversight
AI can automate major components of CBCT-guided adaptation, but validated triggers, end-to-end QA and patient-outcome evidence remain limited.
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cbct
CBCT-measured muscle loss during RT predicted survival in HPV-positive oropharyngeal cancer
Routine treatment CBCT detected skeletal muscle loss that independently tracked worse survival in 337 patients with HPV-positive oropharyngeal cancer.
CBCT-guided online adaptation consistently improved dosimetry, but clinical evidence remains limited
Across 127 studies, CBCT-guided online adaptation repeatedly improved target coverage and OAR sparing, while evidence for better clinical outcomes remained sparse.
CBCT dose changes predicted adaptive radiotherapy benefit better than volume changes
Week-three CBCT dose changes predicted head and neck adaptive radiotherapy benefit with AUC 0.78 versus 0.54 using volume changes.
HyperSight CBCT approached simulation-CT dosimetry for offline adaptive breast radiotherapy
HyperSight reduced PTV dose-recalculation deviations versus Halcyon 3.1 while using a lower imaging dose in 12 breast radiotherapy patients.
Antiscatter grid sharply improved proton CBCT accuracy and soft-tissue contrast
A 2D antiscatter grid reduced soft-tissue CT-number error from 169 to 38 HU at unchanged imaging dose.
CBCT-derived synthetic CT predicted head and neck replanning with 92% sensitivity and specificity
DART predicted clinically triggered head and neck adaptation with 92% sensitivity and specificity using a unified 2-Gy dosimetric threshold.
Deep learning reduced combined truncation and metal artifacts in half-detector CBCT
HD-TMAR improved metal-region PSNR from 25.5 to 35.5 dB in simulated half-detector CBCT while preserving dental anatomy.
Expiratory-phase CBCT reduced respiratory blurring during pancreatic SBRT
Repeated end-expiratory breath-hold CBCT achieved boundary sharpness statistically equivalent to daily CT in 10 pancreatic SBRT patients.
First on-treatment CBCT best predicted lung radiotherapy response in a small cohort
Adding the first treatment CBCT improved response and survival prediction, while additional scans progressively reduced classification performance.
Early CBCT shifts failed to predict dosimetric compromise in head and neck VMAT
Early three-dimensional CBCT shifts performed no better than chance for identifying patients with at least 3% PTV coverage loss.
HyperSight protocol selection substantially changed CBCT organ dose
Low Dose HyperSight protocols reduced exposure by 55%, while Slow and Large protocols increased imaging dose and accentuated secondary-risk estimates.
Deep learning reconstructed one-minute gated CBCT for pancreatic radiotherapy
Deep-learning reconstruction produced pancreatic gated cone-beam computed tomography comparable with conventional imaging while reducing estimated acquisition time and imaging dose.
Fraction 15 was optimal for one-time offline replanning in head and neck proton therapy
A single offline replan at fraction 15 captured most achievable dosimetric benefit in simulated head and neck proton therapy.
Posterior tumour drift threatens lung stereotactic ablative radiotherapy target coverage
In free-breathing lung stereotactic ablative radiotherapy, posterior drift exceeded the 4-millimetre margin in 15.7% of patients within 20 minutes.