International consensus defines target volumes for skull base chordoma radiotherapy
PTCOG experts recommend two CTVs covering the clivus and full preoperative tumor bed with anatomy-adapted margins after surgery.
Tag
chordoma
Fat saturation destabilized most MRI radiomics features used for radionecrosis prediction
Only 10.7% of T2 MRI radiomics features remained highly stable across fat-saturation protocols, and stability filtering improved prediction.
Multi-RBE LET optimization increased target LET by 29% in sacral chordoma
Multi-RBE carbon-ion optimization increased near-minimum GTV LET by 29.2% while maintaining conventional dose coverage and interfraction robustness.
More hypofractionated carbon-ion therapy increased sacral fractures without improving survival
Carbon-ion schedules produced similar tumour outcomes, but sacral insufficiency fractures occurred in 47% versus 24% with 4 Gy(RBE) fractions.
Combined dose–LET model predicted temporal lobe necrosis after skull-base proton therapy
Temporal lobe volumes receiving high dose or moderate dose with high LET jointly predicted grade 2 or higher necrosis.
Carbon ion re-irradiation showed feasible salvage outcomes in recurrent pelvic sarcoma
High-dose carbon ion re-irradiation achieved 83.1% 3-year survival with no grade 4 toxicity in recurrent pelvic sarcoma.
Direct cord robust optimization preserved target coverage near the spinal cord
In ten paraspinal chordoma plans, direct cord robust optimization improved coverage and robustness while maintaining acceptable spinal cord doses.