Longer interval to surgery predicted response after preoperative SBRT for luminal breast cancer
Preoperative SBRT produced a pooled 21.4% pathological complete response rate, with irradiation-to-surgery interval strongly associated with response.
Tag
early-breast
Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.
Internal mammary node response may reveal occult disease in early breast cancer
Nearly 40% of visible internal mammary nodes regressed after chemotherapy, including 22% in patients without axillary nodal disease.
Hypofractionated SIB reduced acute dermatitis in the randomized HYPOSIB trial
Grade 2 dermatitis fell from 38.6% to 25.3% with 16-fraction whole-breast radiotherapy plus simultaneous integrated boost.
Fat necrosis remained low after single-fraction stereotactic partial breast irradiation
Single-fraction GammaPod partial breast irradiation produced 12.1% fat necrosis and 4.1% symptomatic fat necrosis in a phase 2 trial.
Partial breast irradiation projected lower secondary lung cancer risk than whole breast irradiation
Partial breast irradiation projected lower lifetime secondary lung cancer risk than whole breast irradiation in Korean early-stage breast cancer cohorts.
Respiratory motion remained small during postoperative whole-breast radiotherapy.
Mean breast target displacement was below 1.3 mm in every direction, with calculated respiratory margins of approximately 1 mm.
Five-fraction partial breast irradiation with helical tomotherapy showed favorable dosimetry and mild toxicity
Five-fraction helical tomotherapy achieved favorable organ sparing, while the planning target volume-to-breast ratio was associated with higher ipsilateral breast dose.