Extensive coronary calcification on breast RT planning CT predicted ischemic heart disease
All six ischemic events occurred in patients with extensive coronary calcification on breast RT simulation CT, versus none with absent or mild calcification.
Tag
early-breast
Longer interval to surgery predicted response after preoperative SBRT for luminal breast cancer
Preoperative SBRT produced a pooled 21.4% pathological complete response rate, with irradiation-to-surgery interval strongly associated with response.
Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.
Internal mammary node response may reveal occult disease in early breast cancer
Nearly 40% of visible internal mammary nodes regressed after chemotherapy, including 22% in patients without axillary nodal disease.
Hypofractionated SIB reduced acute dermatitis in the randomized HYPOSIB trial
Grade 2 dermatitis fell from 38.6% to 25.3% with 16-fraction whole-breast radiotherapy plus simultaneous integrated boost.
Fat necrosis remained low after single-fraction stereotactic partial breast irradiation
Single-fraction GammaPod partial breast irradiation produced 12.1% fat necrosis and 4.1% symptomatic fat necrosis in a phase 2 trial.
Partial breast irradiation projected lower secondary lung cancer risk than whole breast irradiation
Partial breast irradiation projected lower lifetime secondary lung cancer risk than whole breast irradiation in Korean early-stage breast cancer cohorts.
Respiratory motion remained small during postoperative whole-breast radiotherapy.
Mean breast target displacement was below 1.3 mm in every direction, with calculated respiratory margins of approximately 1 mm.
Five-fraction partial breast irradiation with helical tomotherapy showed favorable dosimetry and mild toxicity
Five-fraction helical tomotherapy achieved favorable organ sparing, while the planning target volume-to-breast ratio was associated with higher ipsilateral breast dose.