Single-fraction SABR matched multi-fraction outcomes in early-stage NSCLC
In 778 patients, single-fraction SABR showed similar local failure, survival and toxicity to three- or four-fraction treatment.
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International consensus defines target volumes for skull base chordoma radiotherapy
PTCOG experts recommend two CTVs covering the clivus and full preoperative tumor bed with anatomy-adapted margins after surgery.
Memantine preserved cognition after radiotherapy for brain metastases in randomized trial
Memantine preserved 6-month cognition versus placebo after radiotherapy for brain metastases, with benefits also seen in quality of life.
45-Gy EQD2 elective nodal irradiation maintained 97% regional control in nasopharyngeal cancer
In 752 NPC patients, 45-Gy EQD2 elective nodal irradiation achieved 97.3% 5-year regional control with only 0.7% elective-volume failures.
Adjuvant radiotherapy halved recurrence risk after complete resection of atypical meningioma
ROAM/EORTC-1308 improved 5-year disease-free survival from 64.3% to 79.9% after complete resection of WHO grade 2 meningioma.
Modern neck radiotherapy was associated with better locoregional control in advanced thyroid cancer
In advanced differentiated thyroid cancer, IMRT/VMAT was associated with a 61% lower hazard of locoregional relapse or death.
Most pT4 laryngeal cancer patients started postoperative RT beyond six weeks
Only 21% started PORT within 42 days after laryngectomy, while each additional week of delay was associated with 3.7% higher mortality.
National audit-driven changes halved severe late GI toxicity after prostate radiotherapy
After a national audit triggered pathway redesign, severe late GI toxicity after prostate EBRT fell from 16% to 7.5%.
Omitting CTV reduced toxicity without compromising outcomes in limited-stage SCLC
After matching 530 patients, CTV omission preserved survival and recurrence patterns while substantially reducing pneumonitis and esophagitis.
Adaptive IMPT preserved gross tumor dose despite frequent ITV undercoverage in esophageal cancer
ITV underdosage occurred in 21% of distal esophageal IMPT patients, yet no GTV underdosage occurred and tumor response was unchanged.
EBV status did not predict failure after nasopharyngeal cancer RT in Denmark
In 331 Danish NPC patients, five-year failure rates were similar by EBV status, while distant relapse was concentrated in locally advanced disease.
Performance status predicted patient-reported toxicity better than age after head and neck RT
Patients aged ≥70 reported similar or lower symptom burden, whereas PS ≥2 consistently predicted worse toxicity and slower recovery after radical RT.
Two salvage HDR brachytherapy schedules produced similar outcomes in recurrent prostate cancer
In 223 previously irradiated patients, 3×10 Gy and 2×13 Gy salvage HDR brachytherapy produced similar disease control and late toxicity.
Proton SBRT achieved 77% two-year local control in high-risk lung tumors
In a prospective proton registry enriched for ultracentral, large, and re-irradiated lung tumors, two-year local control was 77% with no grade ≥3 toxicity.
PET-directed nodal RT plus temporary ADT showed durable 10-year prostate cancer outcomes
PET-directed elective nodal RT plus temporary ADT yielded 77% 10-year overall survival with low grade 3 GU and GI toxicity.