Prolonged first-generation antiandrogens showed no survival benefit with prostate radiotherapy
Extending first-generation antiandrogen therapy beyond short-term use was not associated with better survival and may increase early ADT discontinuation.
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High relevance
Hydrogel spacers reduced invasive treatment for radiation proctitis after prostate radiotherapy
Hydrogel spacer placement was associated with a 74% lower risk of gastrointestinal endoscopic hemostasis after prostate radiotherapy.
ESTRO defines clinical standards for high-dose thoracic reirradiation in NSCLC
ESTRO recommends selective high-dose thoracic reirradiation with comprehensive staging, limited target volumes and formal cumulative dose assessment.
Durvalumab improved 2-year progression-free survival after chemoradiotherapy in real-world stage III NSCLC
Consolidation durvalumab after concurrent chemoradiotherapy halved the adjusted risk of progression or death at two years in real-world stage III NSCLC.
Postoperative radiotherapy provided better quality of life and value in oral cavity cancer
Postoperative conventional radiotherapy caused fewer head-and-neck symptoms and dominated preoperative accelerated radiotherapy in the five-year cost-utility analysis.
FDG-PET and multiparametric MRI did not reliably predict pCR in esophageal cancer
Combined FDG-PET and multiparametric MRI achieved only modest pCR prediction after neoadjuvant chemoradiotherapy, with a cross-validated AUC of 0.65.
Higher CTV minimum dose predicts local control after separation surgery and spine SBRT
Higher postoperative CTV minimum BED10 was associated with lower local failure after separation surgery and spine SBRT.
High-dose-rate brachytherapy monotherapy achieved durable prostate cancer control
High-dose-rate brachytherapy monotherapy achieved 86% biochemical control at median 13-year follow-up in localized prostate cancer.
Prophylactic cranial irradiation outperformed magnetic resonance imaging surveillance in limited-stage small cell lung cancer
Prophylactic cranial irradiation was associated with longer survival and brain metastasis-free survival than magnetic resonance imaging surveillance.
International consensus supported acute radiation dermatitis scoring tool
An international Delphi panel approved a three-step acute radiation dermatitis tool integrating patient-reported symptoms and clinician assessment.
Partial breast irradiation projected lower secondary lung cancer risk than whole breast irradiation
Partial breast irradiation projected lower lifetime secondary lung cancer risk than whole breast irradiation in Korean early-stage breast cancer cohorts.
Simultaneous integrated boost chemoradiotherapy was linked to better disease-free survival in anal cancer
Simultaneous integrated boost radiotherapy was associated with 96% two-year disease-free survival versus 70% with sequential boost in anal cancer.
Daily adaptive prostate stereotactic body radiotherapy improved target coverage
Daily cone-beam computed tomography-based adaptation improved prostate stereotactic body radiotherapy target coverage, but organ-at-risk dose benefits were inconsistent.
Simulation-free single-fraction radiotherapy was feasible for non-spine metastases
Diagnostic computed tomography-based single-fraction radiotherapy was feasible for selected non-spine palliative metastases, with no grade 3 or higher acute toxicity.
Sandwich chemoradiotherapy showed favorable local control in early natural killer/T-cell lymphoma
Three-year locoregional recurrence-free survival was 90.8%, with most locoregional recurrences occurring within or near the radiation field.