Twenty-fraction cervical chemoradiation shortened treatment but raised a late GI toxicity signal
44 Gy in 20 fractions shortened cervical cancer treatment by seven days but showed numerically more severe late GI toxicity.
Tag
hypofractionation
Baseline urinary symptoms predicted late GU toxicity after hypofractionated prostate RT
Each one-point increase in baseline IPSS independently increased the odds of late grade ≥2 GU toxicity by 11%.
Aggressive concurrent hypofractionation increased fatal toxicity in unresectable stage II–III NSCLC
Across 26 studies, fatal toxicity clustered when BED10 >100 Gy was delivered to the whole tumor with concurrent platinum chemotherapy.
Two-week PACTUS radiotherapy showed feasibility in frail patients with anal cancer
PACTUS 40 Gy/10 produced 30-month median survival in 28 selected frail patients, but incomplete response and toxicity data limit efficacy conclusions.
Modern fractionation data challenge fixed α/β assumptions across tumor types
A systematic review argues that α/β is disease- and context-specific rather than a fixed biological constant across radiotherapy settings.
Sequential hypofractionation improved locoregional control in locally advanced NSCLC
Sequential 55 Gy in 20 fractions achieved 62% three-year locoregional control, outperforming conventionally fractionated sequential chemoradiotherapy without greater toxicity.
Moderately hypofractionated regional nodal irradiation had 6.4% three-year lymphedema
With 42.56 Gy in 16 fractions, three-year lymphedema was 6.4%, with no new events through five years.
Twenty-fraction head and neck radiotherapy was feasible in older and comorbid patients
Ninety-five percent completed 55 Gy in 20 fractions, with encouraging outcomes in early p16-positive oropharyngeal cancer despite substantial acute toxicity.
Reduced-volume MR-guided RT was feasible in glottic cancer, with two recurrences
Reduced-volume MR-guided RT caused no grade ≥3 toxicity, but two of ten patients developed in-field recurrence after five-fraction treatment.
Hypofractionated salvage radiotherapy did not improve biochemical control after prostatectomy
Four-year biochemical control was similar with 65 Gy in 26 fractions and 66 Gy in 33 fractions, while gastrointestinal toxicity was higher.
Early response-adapted TNT preserved the rectum in a minority of selected patients
Two-year sustained complete response was 36% after short-course RT and response-adapted FOLFOX4, while near-complete responses frequently regrew.
Three-cycle thoracic Quad Shot was feasible with concurrent systemic therapy in metastatic NSCLC
Three Quad Shot cycles caused limited high-grade toxicity, no systemic-therapy delays and frequent thoracic symptom improvement.
Short-course radiotherapy may be a stronger immunotherapy partner in rectal cancer
Recent trials report 40–61% pathologic complete response with short-course radiotherapy plus immunotherapy, but mature comparative outcomes remain unavailable.
Daily adaptation supported 17-fraction definitive chemoradiotherapy for cervical cancer
Daily online adaptation improved pelvic target coverage during 17-fraction cervical chemoradiotherapy, with 10% grade ≥3 gastrointestinal toxicity.
Hypofractionated SIB reduced acute dermatitis in the randomized HYPOSIB trial
Grade 2 dermatitis fell from 38.6% to 25.3% with 16-fraction whole-breast radiotherapy plus simultaneous integrated boost.