Modern neck radiotherapy was associated with better locoregional control in advanced thyroid cancer
In advanced differentiated thyroid cancer, IMRT/VMAT was associated with a 61% lower hazard of locoregional relapse or death.
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imrt
VMAT exposed less circulating blood than IMRT in glioma simulations
VMAT exposed less circulating blood than IMRT, but modeled immune-cell depletion differed by only one percentage point after 30 fractions.
Hemithoracic radiotherapy after surgery achieved durable control in pleural thymoma
After surgery and 14 Gy hemithoracic radiotherapy, five-year progression-free survival was 50.8% with only one grade 3 pneumonitis.
Overlap-adapted dose reduction lowered temporal lobe injury in T4 nasopharyngeal cancer
Reducing the PTV–temporal lobe overlap dose to 66 Gy lowered five-year radiographic temporal lobe injury from 36.2% to 23.2%.
On Ethos, intensity-modulated radiotherapy generated faster and spared several pelvic organs better than arc therapy
Nine-field intensity-modulated radiotherapy shortened overall planning-plus-delivery time and improved several pelvic dose metrics compared with volumetric modulated arc therapy.
Deep learning generated deliverable lymphoma intensity-modulated plans but remained dosimetrically inferior
Deep learning produced machine-deliverable lymphoma plans across heterogeneous anatomy, but target coverage and hot spots remained inferior to reference planning.
Pulsed photon reirradiation showed 27-month median progression-free survival in recurrent meningioma
Temporally modulated pulsed radiotherapy achieved a median progression-free survival of 27.2 months in large, previously irradiated recurrent meningiomas.
Interpretable autoencoder detected anomalous IMRT plans with high discrimination
An autoencoder identified anomalous IMRT plans with an area under the curve of 0.98 and explained which parameters drove each alert.
Simultaneous integrated boost chemoradiotherapy was linked to better disease-free survival in anal cancer
Simultaneous integrated boost radiotherapy was associated with 96% two-year disease-free survival versus 70% with sequential boost in anal cancer.
Sandwich chemoradiotherapy showed favorable local control in early natural killer/T-cell lymphoma
Three-year locoregional recurrence-free survival was 90.8%, with most locoregional recurrences occurring within or near the radiation field.
Higher ovarian dose was linked to ovarian insufficiency after transposition in cervical cancer
All patients receiving more than 8 Gy mean dose or 16 Gy maximum dose to the least exposed ovary developed premature ovarian insufficiency.
Thyroid complication models showed only moderate long-term validation in head and neck cancer
Existing thyroid complication models showed moderate performance and frequent miscalibration in long-term head and neck cancer survivorship.
Target-prioritized intensity modulated radiotherapy appeared feasible in nasopharyngeal carcinoma near the spinal cord
No radiation myelopathy was observed after target-prioritized intensity modulated radiotherapy for selected nasopharyngeal carcinoma near the spinal cord.
No isolated failures in omitted nodal regions with reduced elective irradiation for early oropharyngeal cancer
Definitive intensity-modulated radiotherapy alone achieved 93.0% three-year overall survival, with no recurrence solely within omitted prophylactic nodal regions.
Explainable machine learning predicts structure-specific quality assurance performance in intensity-modulated radiotherapy
Anatomy- and dose-based machine learning predicted gamma passing rates accurately for organs at risk, but less reliably for target volumes.