ARIA phase I will test five-fraction MR-guided RT for early glottic cancer
The 20-patient ARIA study will test 5×8.5 Gy MR-guided adaptive RT with gating for cT1–2N0M0 glottic cancer.
Tag
larynx
Most pT4 laryngeal cancer patients started postoperative RT beyond six weeks
Only 21% started PORT within 42 days after laryngectomy, while each additional week of delay was associated with 3.7% higher mortality.
Total laryngectomy improved local control over chemoradiotherapy in selected advanced laryngeal cancer
Surgery provided substantially better local control in T3–T4a N0–N1 laryngeal cancer, while disease-specific survival remained similar and CRT preserved laryngeal function in 79%.
Reduced-volume MR-guided RT was feasible in glottic cancer, with two recurrences
Reduced-volume MR-guided RT caused no grade ≥3 toxicity, but two of ten patients developed in-field recurrence after five-fraction treatment.
NanOx incompletely predicted laryngeal cancer cell survival across a helium Bragg peak
NanOx predictions differed from measured laryngeal cancer cell survival by 20–37% and overestimated the distal biological gradient.
FDG-PET-guided dose escalation did not improve control in advanced oropharyngeal and laryngopharyngeal cancers
Escalating metabolically active disease to 73.5 Gy did not improve locoregional control, disease-free survival, or overall survival versus 66 Gy.