Combined dose–LET model predicted temporal lobe necrosis after skull-base proton therapy
Temporal lobe volumes receiving high dose or moderate dose with high LET jointly predicted grade 2 or higher necrosis.
Tag
LET
Dose-dependent linear energy transfer constraints supported proton toxicity interpretation
Dose-dependent linear energy transfer constraints aligned with published proton toxicity data better than fixed threshold approaches.
Combined dose and linear energy transfer predict local control after carbon-ion radiotherapy
High-dose, high-linear-energy-transfer target coverage stratified local control after carbon-ion radiotherapy for adenoid cystic carcinoma.