Simulation-free adaptive lung SBRT was feasible in the ONE STOP pilot
Eight of ten patients completed simulation-free single-fraction adaptive lung SBRT, with treatment taking a median 72 minutes.
Tag
lung
4DCT ventilation accurately predicted lung function after cancer resection
4DCT ventilation predicted postoperative FEV1, FVC, and DLCO with concordance coefficients of 0.88–0.91 in the LIME trial.
CT–MRI fusion improved contrast-free lung perfusion mapping for radiotherapy planning
Multimodal CT–MRI perfusion maps matched SPECT better than single-modality methods and reduced high-function lung dose in exploratory planning.
Early ventilation changes predicted end-of-treatment lung function after radiotherapy
Early-treatment ventilation direction persisted to treatment completion in most photon- and proton-treated patients, with the prediction model explaining 89% of variation.
FLASH proton therapy for lung cancer remains preclinical despite technical progress
Preclinical lung studies support normal-tissue sparing, but uncertain biological thresholds, dose conformity, and respiratory motion still prevent clinical implementation.
ECHO automated lung planning across seven fractionation schedules in routine practice
ECHO generated consistent lung IMRT and VMAT plans while reducing active planner time by approximately 90 minutes per case.
First on-treatment CBCT best predicted lung radiotherapy response in a small cohort
Adding the first treatment CBCT improved response and survival prediction, while additional scans progressively reduced classification performance.
Single-fraction lung brachytherapy produced progressive consolidation and fibrotic retraction
Pulmonary consolidation was common after single-fraction interstitial brachytherapy and frequently evolved into progressive retraction during the second year.
High geometric agreement did not guarantee physician acceptance of AI contours
Thoracic AI contours showed strong geometric and dosimetric agreement, but physicians still rejected some heart and oesophageal contours.
Cardiac toxicity occurred in 8% after central and ultracentral lung SBRT
Symptomatic grade ≥2 cardiac toxicity occurred in 8% after central or ultracentral lung SBRT, typically developing more than one year after treatment.
FLASH attenuated inflammatory and pro-fibrotic lung transcription after irradiation
In mice, FLASH reduced acute chemokine and later macrophage-associated transcription versus conventional irradiation, without significantly reducing collagen deposition.
RapidPlan lung SBRT model used gEUD objectives for reproducible planning
A RapidPlan lung SBRT model generated clinically acceptable plans in 52% of validation cases on first optimization.
Federated learning improved radiation pneumonitis prediction across lung cancer datasets
A center-specific federated learning model predicted grade 2 or higher radiation pneumonitis with stable cross-dataset performance.
Photon-counting computed tomography estimated physical density with 5.5% phantom error
Photon-counting computed tomography generated effective atomic number and physical density images directly from virtual monoenergetic images.
Posterior tumour drift threatens lung stereotactic ablative radiotherapy target coverage
In free-breathing lung stereotactic ablative radiotherapy, posterior drift exceeded the 4-millimetre margin in 15.7% of patients within 20 minutes.