Single-fraction lung SBRT achieved 100% estimated one-year local control in selected patients
Single-fraction SBRT achieved 100% estimated 12-month local control without grade ≥3 toxicity in a selected 49-patient cohort.
Tag
lung
No lung subregion strategy clearly improved radiation pneumonitis prediction
Whole-lung, physical-dose and BED3 models performed similarly externally, with the best complete-model AUC only 0.684 and inadequate calibration.
Severe pneumonitis developed after carbon-ion RT following nivolumab in lung cancer
Life-threatening bilateral pneumonitis with concurrent Pneumocystis infection developed three days after carbon-ion RT in a patient previously treated with nivolumab.
Breathing-phase targeting reduced normal-tissue dose in proton lung radiotherapy
Planning on selected respiratory phases reduced lung, heart and esophageal dose, but the optimal phase differed by toxicity endpoint.
Simulation-free adaptive lung SBRT was feasible in the ONE STOP pilot
Eight of ten patients completed simulation-free single-fraction adaptive lung SBRT, with treatment taking a median 72 minutes.
4DCT ventilation accurately predicted lung function after cancer resection
4DCT ventilation predicted postoperative FEV1, FVC, and DLCO with concordance coefficients of 0.88–0.91 in the LIME trial.
CT–MRI fusion improved contrast-free lung perfusion mapping for radiotherapy planning
Multimodal CT–MRI perfusion maps matched SPECT better than single-modality methods and reduced high-function lung dose in exploratory planning.
Early ventilation changes predicted end-of-treatment lung function after radiotherapy
Early-treatment ventilation direction persisted to treatment completion in most photon- and proton-treated patients, with the prediction model explaining 89% of variation.
FLASH proton therapy for lung cancer remains preclinical despite technical progress
Preclinical lung studies support normal-tissue sparing, but uncertain biological thresholds, dose conformity, and respiratory motion still prevent clinical implementation.
ECHO automated lung planning across seven fractionation schedules in routine practice
ECHO generated consistent lung IMRT and VMAT plans while reducing active planner time by approximately 90 minutes per case.
First on-treatment CBCT best predicted lung radiotherapy response in a small cohort
Adding the first treatment CBCT improved response and survival prediction, while additional scans progressively reduced classification performance.
Single-fraction lung brachytherapy produced progressive consolidation and fibrotic retraction
Pulmonary consolidation was common after single-fraction interstitial brachytherapy and frequently evolved into progressive retraction during the second year.
High geometric agreement did not guarantee physician acceptance of AI contours
Thoracic AI contours showed strong geometric and dosimetric agreement, but physicians still rejected some heart and oesophageal contours.
Cardiac toxicity occurred in 8% after central and ultracentral lung SBRT
Symptomatic grade ≥2 cardiac toxicity occurred in 8% after central or ultracentral lung SBRT, typically developing more than one year after treatment.
FLASH attenuated inflammatory and pro-fibrotic lung transcription after irradiation
In mice, FLASH reduced acute chemokine and later macrophage-associated transcription versus conventional irradiation, without significantly reducing collagen deposition.