TFDP2-PDK3 metabolic signaling drove nasopharyngeal carcinoma radioresistance
TFDP2 activated PDK3, shifted nasopharyngeal carcinoma cells toward glycolysis, and reduced radiation response in cellular and xenograft models.
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nasopharynx
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction has the strongest evidence, while proton therapy and immunotherapy-based de-escalation remain less established.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction and sequential chemoradiotherapy have the strongest evidence, while proton and immunotherapy-based approaches remain less established.
CT imaging features improved local and distant control prediction in nasopharyngeal carcinoma
Planning CT features added prognostic information for local and distant control but did not significantly improve overall or progression-free survival prediction.
Medial retropharyngeal nodes were involved in 2.95% of non-endemic nasopharyngeal cancers
Medial retropharyngeal nodes were involved in 2.95% of German cases, but no recurrence occurred among patients whose elective volume omitted the region.
Target-prioritized intensity modulated radiotherapy appeared feasible in nasopharyngeal carcinoma near the spinal cord
No radiation myelopathy was observed after target-prioritized intensity modulated radiotherapy for selected nasopharyngeal carcinoma near the spinal cord.
Weekly synthetic computed tomography identified structure-specific replanning triggers in nasopharyngeal carcinoma
Weekly monitoring identified week 2 triggers for nodal targets and contralateral parotids, with later week 4 triggers for primary targets.
Virtual contrast-enhanced MRI matched gadolinium-enhanced imaging for diagnosis, staging, and tumor delineation.
98.98% of virtual contrast-enhanced MRI scans were rated suitable for diagnosis, and 92.33% for tumor delineation.