Radiomic shape features improved xerostomia prediction after nasopharyngeal radiotherapy
Adding parotid–target overlap shape features improved moderate-to-severe xerostomia prediction from AUC 0.66 to 0.78.
Tag
nasopharynx
Multimodal AI proposed major surveillance reduction after stage II NPC
External validation achieved AUC 0.986, while modeled risk-adapted surveillance reduced visits by 90.0–98.5% and identified every observed failure.
Higher tumor LET predicted better local control after carbon-ion NPC reirradiation
Recurrent NPC with GTV LETd99 ≥39.4 keV/μm had 94.4% versus 65.3% two-year local control after carbon-ion reirradiation.
Non-endemic nasopharyngeal cancer showed similar locoregional and distant failure rates
Five-year overall survival was 71%, with most distant failures occurring during the first three years after treatment.
Induction TPF did not improve three-year PFS over adjuvant PF in locally advanced NPC
Three-year PFS was 79.0% with induction TPF versus 74.5% with adjuvant PF, with substantially different toxicity profiles.
Updated level IVa contouring reduced predicted hypothyroidism risk in nasopharyngeal cancer
Updated level IVa delineation reduced predicted hypothyroidism from 43.9% to 34.9% without compromising target coverage.
3D-printed oral stents were associated with less toxicity after nasopharyngeal radiotherapy
Patient-specific stents improved tongue and parotid stability and were associated with substantially less hearing loss, dysphagia and dysgeusia.
TFDP2-PDK3 metabolic signaling drove nasopharyngeal carcinoma radioresistance
TFDP2 activated PDK3, shifted nasopharyngeal carcinoma cells toward glycolysis, and reduced radiation response in cellular and xenograft models.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction has the strongest evidence, while proton therapy and immunotherapy-based de-escalation remain less established.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction and sequential chemoradiotherapy have the strongest evidence, while proton and immunotherapy-based approaches remain less established.
CT imaging features improved local and distant control prediction in nasopharyngeal carcinoma
Planning CT features added prognostic information for local and distant control but did not significantly improve overall or progression-free survival prediction.
Medial retropharyngeal nodes were involved in 2.95% of non-endemic nasopharyngeal cancers
Medial retropharyngeal nodes were involved in 2.95% of German cases, but no recurrence occurred among patients whose elective volume omitted the region.
Target-prioritized intensity modulated radiotherapy appeared feasible in nasopharyngeal carcinoma near the spinal cord
No radiation myelopathy was observed after target-prioritized intensity modulated radiotherapy for selected nasopharyngeal carcinoma near the spinal cord.
Weekly synthetic computed tomography identified structure-specific replanning triggers in nasopharyngeal carcinoma
Weekly monitoring identified week 2 triggers for nodal targets and contralateral parotids, with later week 4 triggers for primary targets.
Virtual contrast-enhanced MRI matched gadolinium-enhanced imaging for diagnosis, staging, and tumor delineation.
98.98% of virtual contrast-enhanced MRI scans were rated suitable for diagnosis, and 92.33% for tumor delineation.