45-Gy EQD2 elective nodal irradiation maintained 97% regional control in nasopharyngeal cancer
In 752 NPC patients, 45-Gy EQD2 elective nodal irradiation achieved 97.3% 5-year regional control with only 0.7% elective-volume failures.
Tag
nasopharynx
EBV status did not predict failure after nasopharyngeal cancer RT in Denmark
In 331 Danish NPC patients, five-year failure rates were similar by EBV status, while distant relapse was concentrated in locally advanced disease.
Second malignancy risk reached 6.7% at 15 years after IMRT for nasopharyngeal cancer
Among long-term NPC survivors treated with IMRT, radiation-related second malignancy incidence reached 6.66% at 15 years.
Advanced extranodal extension improved N3 risk identification in nasopharyngeal carcinoma
Adding advanced extranodal extension to N3 modestly improved prognostic discrimination and identified patients with substantially greater distant failure risk.
Statistical process control reduced organ doses in nasopharyngeal IMRT planning
SPC-guided planning reduced larynx and parotid doses without compromising target coverage in a 200-patient retrospective nasopharyngeal carcinoma series.
Overlap-adapted dose reduction lowered temporal lobe injury in T4 nasopharyngeal cancer
Reducing the PTV–temporal lobe overlap dose to 66 Gy lowered five-year radiographic temporal lobe injury from 36.2% to 23.2%.
Radiomic shape features improved xerostomia prediction after nasopharyngeal radiotherapy
Adding parotid–target overlap shape features improved moderate-to-severe xerostomia prediction from AUC 0.66 to 0.78.
Multimodal AI proposed major surveillance reduction after stage II NPC
External validation achieved AUC 0.986, while modeled risk-adapted surveillance reduced visits by 90.0–98.5% and identified every observed failure.
Higher tumor LET predicted better local control after carbon-ion NPC reirradiation
Recurrent NPC with GTV LETd99 ≥39.4 keV/μm had 94.4% versus 65.3% two-year local control after carbon-ion reirradiation.
Non-endemic nasopharyngeal cancer showed similar locoregional and distant failure rates
Five-year overall survival was 71%, with most distant failures occurring during the first three years after treatment.
Induction TPF did not improve three-year PFS over adjuvant PF in locally advanced NPC
Three-year PFS was 79.0% with induction TPF versus 74.5% with adjuvant PF, with substantially different toxicity profiles.
Updated level IVa contouring reduced predicted hypothyroidism risk in nasopharyngeal cancer
Updated level IVa delineation reduced predicted hypothyroidism from 43.9% to 34.9% without compromising target coverage.
3D-printed oral stents were associated with less toxicity after nasopharyngeal radiotherapy
Patient-specific stents improved tongue and parotid stability and were associated with substantially less hearing loss, dysphagia and dysgeusia.
TFDP2-PDK3 metabolic signaling drove nasopharyngeal carcinoma radioresistance
TFDP2 activated PDK3, shifted nasopharyngeal carcinoma cells toward glycolysis, and reduced radiation response in cellular and xenograft models.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction has the strongest evidence, while proton therapy and immunotherapy-based de-escalation remain less established.