Heterogeneous EclipseRT plus PD-1 therapy was feasible in nine bulky NSCLC patients
EclipseRT plus PD-1 blockade produced five responses among nine bulky NSCLC patients without grade ≥3 treatment-related toxicity.
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nsclc
Iodine-125 brachytherapy preserved lung function in high-risk NSCLC patients
CT-guided iodine-125 implantation achieved 60.7% one-year response without grade ≥3 pneumonitis in patients with severe pulmonary dysfunction.
Three-cycle thoracic Quad Shot was feasible with concurrent systemic therapy in metastatic NSCLC
Three Quad Shot cycles caused limited high-grade toxicity, no systemic-therapy delays and frequent thoracic symptom improvement.
Mechanistic model predicted six-month lymphocyte depletion after lung SBRT
A circulation-based model predicted post-SBRT lymphocyte trajectories and linked a higher predicted lymphocyte nadir with better survival.
ELCC 2026 highlights expanding roles for radiotherapy across modern thoracic oncology
ELCC 2026 highlighted growing integration of SBRT and thoracic radiotherapy with targeted therapy, immunotherapy and biomarker-guided treatment selection.
Anatomy-based traffic lights missed important dose changes during lung radiotherapy
In 604 fractions, traffic-light alerts partially identified target undercoverage but were unreliable proxies for organ-at-risk dose changes.
Robust optimization minimized lung-dose trade-offs in carbon-ion planning for stage I NSCLC
Robust optimization improved target coverage with less lung-dose penalty than margin expansion, while density override was particularly useful for solid tumors.
Deep learning generated CT-free PET with near-zero SUV bias in NSCLC
Emission-only PET synthesis produced 0.72% SUVmax bias and 99.2% contrast recovery in an independent NSCLC test cohort.
Time-series CT radiomics predicted rib fracture after lung SBRT with 0.79 validation AUC
A longitudinal CT radiomics model identified post-SBRT rib fracture risk with 85% sensitivity and 71% specificity in validation.
Longitudinal muscle loss and myocardial remodeling tracked worse survival after non-small cell lung cancer radiotherapy
Skeletal muscle loss and substantial left ventricular mass changes on follow-up imaging were strongly associated with poorer survival after curative radiotherapy.
AI-derived LAD dose reproduced survival stratification in RTOG 0617
Automated LAD contours reproduced the association between coronary dose and survival in 460 stage III NSCLC patients, although performance varied by model.
Hybrid CT features predicted symptomatic pneumonitis after locally advanced NSCLC radiotherapy
A hybrid peri-tumoural CT model achieved an external AUC of 0.828 for predicting grade 2 or higher radiation pneumonitis.
Two-dimensional TCP modeling linked lung tumour control mainly to radiosensitivity heterogeneity
Inter-patient radiosensitivity explained 85–97% of modeled TCP steepness, while uncertainty in delivered dose exceeded uncertainty in local-control estimates.
Earlier lung cancer diagnosis exposed major delays in curative radiotherapy access
In 2024, only 3.2% of English patients began curative radiotherapy within the 49-day target despite rapidly rising demand.
Respiratory gating reduced lung SBRT target volumes and normal-tissue dose
A 30–70% gating window reduced planning target volume by 34% and mean lung dose by 0.75 Gy without compromising coverage.