Automated proton planning reproduced clinical head and neck NTCP estimates within minutes
Automated proton plans reproduced clinical dysphagia and xerostomia estimates closely while reducing optimization time from days to about one hour.
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NTCP
Bowel dose predicted acute diarrhea after both RAPIDO neoadjuvant strategies
Larger irradiated bowel volumes predicted acute diarrhea after both short-course total neoadjuvant treatment and chemoradiation, although discrimination was modest.
Patient-reported neck fibrosis showed dose–response relationships after definitive head and neck radiotherapy
Dose to neck skin, subcutaneous tissue, and sternocleidomastoid muscle predicted fibrosis burden in nonsurgical head and neck cancer survivors.
Lower microvascular health predicted acute radiotherapy toxicity across three cancer cohorts
Lower pretreatment microvascular health was associated with more acute toxicity overall, while disease-specific performance was strongest in breast cancer.
Thyroid complication models showed only moderate long-term validation in head and neck cancer
Existing thyroid complication models showed moderate performance and frequent miscalibration in long-term head and neck cancer survivorship.
High-dose left anterior descending artery exposure was associated with cardiac events after breast radiotherapy
A 40 Gy equivalent dose to at least 18% of the left anterior descending artery was associated with more than twofold risk of cardiac events.