Simulation-free VMAT preserved delivered dose for palliative bone radiotherapy
Diagnostic CT-based VMAT preserved PTV D95 at 99.6% of planned dose across 30 palliative bone RT plans.
Tag
palliative
Integrated rapid palliative RT achieved fast treatment without a dedicated clinic
A routine departmental workflow delivered rapid palliative RT with a median 109-minute treatment process despite having no dedicated rapid-access clinic.
Longer palliative RT courses were associated with substantially more lymphopenia
Compared with 8 Gy in one fraction, five- and ten-fraction regimens were associated with approximately two- and threefold higher odds of lymphopenia.
All-in-one emergency radiotherapy delivered treatment in a median 25 minutes
An integrated CT-linac workflow delivered emergency radiotherapy in 24.7 minutes, with symptom relief in nearly 90% of patients.
Three-cycle thoracic Quad Shot was feasible with concurrent systemic therapy in metastatic NSCLC
Three Quad Shot cycles caused limited high-grade toxicity, no systemic-therapy delays and frequent thoracic symptom improvement.
Prophylactic dexamethasone reduced pain flare after radiotherapy for bone metastases
Across six randomized studies, prophylactic corticosteroids reduced radiation-induced pain-flare risk by 37%, although regimens and safety reporting varied.
Radiotherapy was not associated with longer survival in breast cancer leptomeningeal disease
In 232 women with breast cancer leptomeningeal disease, radiotherapy was not associated with longer overall survival, while systemic therapy was.
Simulation-free CBCT workflow enabled urgent radiotherapy within about two hours
The OSCAR workflow delivered the first urgent or palliative fraction without planning CT in approximately 1 hour 50 minutes.
Re-irradiation was associated with longer survival after pediatric diffuse midline glioma progression
COMPPARE enrolled 2,524 patients from 51 institutions in 52 months, with Black participation reaching 16% of the cohort.
Bone metastasis trials need treatment-intent endpoints beyond pain response
Pain should remain central for symptomatic disease, but prevention, function, local control and skeletal events require separate standardized endpoints.
Higher-BED palliative radiotherapy improved symptoms in rectal cancer
BED >37.5 Gy improved symptomatic control, while 6-month local control remained 46% in frail, elderly, or metastatic rectal cancer.
Dutch survey found wide variation in radiotherapy for unresectable recurrent rectal cancer
Dutch radiation oncologists reported substantial variation in dose, delineation, and follow-up for unresectable locally recurrent rectal cancer.
Machine learning stratified survival after palliative radiotherapy for bone metastases
A decision tree model identified interleukin-8, hemoglobin, and lymphocyte count as key survival predictors after palliative radiotherapy.
Single-fraction radiotherapy matched multifraction treatment for malignant bone tumor pain
Single-fraction external beam radiotherapy provided similar pain relief to multifraction treatment in this meta-analysis of malignant bone tumor pain.
Simulation-free single-fraction radiotherapy was feasible for non-spine metastases
Diagnostic computed tomography-based single-fraction radiotherapy was feasible for selected non-spine palliative metastases, with no grade 3 or higher acute toxicity.