SMART achieved durable local control in pancreatic cancer while distant progression dominated
After 50 Gy in five fractions, local progression was 15% at one year, while distant progression remained the dominant failure pattern.
Tag
pancreatic
Higher SMAD4 expression tracked with fewer distant failures after resected pancreatic cancer
Higher tumor SMAD4 was associated with better disease-free survival and lower distant metastatic risk after resection and adjuvant chemoradiotherapy.
Proton RBE rose sharply beyond the Bragg peak in pancreatic cancer cells
In two PDAC cell lines, measured proton RBE remained near 1.0 through the Bragg peak but rose as high as 6.1 distally.
SBRT is moving beyond palliation in oligometastatic pancreatic cancer
SBRT can provide high local control in selected oligometastatic pancreatic cancer, but randomized survival evidence and patient-selection criteria remain limited.
Updated ASTRO guideline expands radiation therapy across pancreatic cancer settings
ASTRO expands radiation therapy recommendations across locally advanced, recurrent and oligometastatic pancreatic cancer, with new guidance on dose escalation and adaptation.
Expiratory-phase CBCT reduced respiratory blurring during pancreatic SBRT
Repeated end-expiratory breath-hold CBCT achieved boundary sharpness statistically equivalent to daily CT in 10 pancreatic SBRT patients.
Small gastrointestinal PRV margins limited dose increases but did not encompass pancreatic SABR motion
Two- to five-millimetre gastrointestinal margins usually limited delivered dose increases but frequently failed to encompass interfraction organ motion.
ATR inhibition enhanced cytotoxic and immunogenic radiation effects in pancreatic cancer cells
ATR inhibition increased radiation-induced cell killing and inflammatory signalling in KRAS wild-type pancreatic cancer cells, with weaker immunogenic effects in KRAS-mutated cells.
Deep learning reconstructed one-minute gated CBCT for pancreatic radiotherapy
Deep-learning reconstruction produced pancreatic gated cone-beam computed tomography comparable with conventional imaging while reducing estimated acquisition time and imaging dose.
FLASH preserved mitochondrial function in non-tumorigenic pancreatic models
FLASH spared mitochondrial integrity in non-tumorigenic pancreatic models while producing tumour effects comparable with conventional-dose-rate irradiation.
Conventional fractionation substantially reduced gastrointestinal motility–driven interplay in pancreatic proton therapy.
Gastrointestinal motility reduced single-fraction target coverage and broadened organ-at-risk dose ranges, while conventional fractionation substantially attenuated the interplay effect.
Early stereotactic radiotherapy was associated with longer progression-free survival in pancreatic cancer
Adding early stereotactic body radiotherapy to neoadjuvant chemoimmunotherapy was associated with median progression-free survival of 12.5 versus 6.6 months.
Oxygen ions produced greater pancreatic cancer cell killing than carbon ions and photons
Oxygen-ion irradiation showed higher biological effectiveness and more persistent DNA damage than carbon ions or photons in pancreatic cancer cells.
Four-dimensional prompt-gamma imaging detected proton range changes during pancreatic treatment
Four-dimensional prompt-gamma imaging detected clinically relevant proton range shifts associated with anatomical change during pancreatic proton therapy.
Two-hour fasting did not reliably stabilize stomach volume during pancreatic stereotactic radiotherapy
Standardized two-hour fasting produced reproducible stomach volumes in only 42% of patients receiving magnetic resonance-guided pancreatic stereotactic radiotherapy.