Third-course reirradiation provided symptom relief in selected patients with progressive DIPG
Across 12 reported patients receiving at least three radiation courses for DIPG, median survival was 27 months with frequent symptomatic benefit.
Tag
pediatric
VMAT-based pediatric TBI achieved organ sparing with acceptable early clinical outcomes
VMAT-TBI achieved 96.6% mean PTV D95 while keeping mean lung and kidney doses below 9 Gy.
Proton use reached nearly 40% in recent Children’s Oncology Group radiotherapy trials
Across 27 years of COG trials, IMRT/VMAT replaced 3D photons while proton use expanded to nearly 40% of radiotherapy patients.
Eye tracking and imaging features predicted uncertainty in manual brain tumor contours
Behavioral and image-derived features explained 39% of interobserver contour uncertainty during manual brain tumor delineation.
Deep learning reduced pediatric craniospinal target contouring from eight hours to 30 minutes
Automated pediatric CSI contours achieved a mean Dice score of 0.959 and reduced target-delineation time from approximately eight hours to 30 minutes.
Re-irradiation was associated with longer survival after pediatric diffuse midline glioma progression
COMPPARE enrolled 2,524 patients from 51 institutions in 52 months, with Black participation reaching 16% of the cohort.
Sleep adjustment avoided sedation in most pediatric radiotherapy fractions
A structured sleep protocol enabled sedation-free delivery in 96.4% of radiotherapy fractions among children younger than four years.
Children’s Oncology Group guidelines standardize pediatric radiotherapy simulation across treatment sites and techniques
COG guidelines standardize pediatric radiotherapy simulation across treatment sites and techniques
Nationwide play-based programme helped children engage with paediatric radiotherapy
The programme prepared 256 children for radiotherapy and was associated with avoidance of daily general anaesthesia in five selected cases.