Intratumoral polyvinyl chloride was associated with radioresistance in hepatocellular carcinoma
PVC was detected in 37 of 72 HCC tumors and was associated with poorer response and progression-free survival after SBRT, immunotherapy, and bevacizumab.
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preliminary
Lower microvascular health predicted acute radiotherapy toxicity across three cancer cohorts
Lower pretreatment microvascular health was associated with more acute toxicity overall, while disease-specific performance was strongest in breast cancer.
FLASH attenuated inflammatory and pro-fibrotic lung transcription after irradiation
In mice, FLASH reduced acute chemokine and later macrophage-associated transcription versus conventional irradiation, without significantly reducing collagen deposition.
Immuno-Eclipse radiotherapy controlled bulky tumor models through antitumor immunity
Immuno-Eclipse radiotherapy improved bulky tumor control in mice through natural killer and cytotoxic T-cell immunity.
Perioperative immunotherapy with chemoradiation showed encouraging response in resectable gastric and gastroesophageal junction cancer
A single-arm phase 1/2 trial reported a 39.1% pathologic complete response rate among resected patients, with grade 4 toxicities in 10%.
Hydrogen gas inhalation showed exploratory metabolic and toxicity signals during head and neck chemoradiotherapy
Adjunctive hydrogen gas inhalation was associated with numerically fewer moderate toxicities and exploratory serum metabolomic changes during head and neck chemoradiotherapy.
Computed tomography radiomics showed exploratory recurrence signals in mandibular osteoradionecrosis
In 24 surgically confirmed cases, three radiomic features differed nominally between pure osteoradionecrosis and osteoradionecrosis with recurrence.
High lactate dehydrogenase-5 and low lymphocyte infiltration identified higher relapse risk after prostate radiotherapy
Combined high lactate dehydrogenase-5 expression and low tumor-infiltrating lymphocyte density independently identified higher biochemical relapse risk after prostate radiotherapy.
Percussive ventilation enabled imaging and lung stereotactic ablative radiotherapy within one breath-hold
Three of four patients completed final imaging and lung stereotactic ablative radiotherapy within one assisted breath-hold, with only grade 1 adverse events.
Five-fraction partial breast irradiation with helical tomotherapy showed favorable dosimetry and mild toxicity
Five-fraction helical tomotherapy achieved favorable organ sparing, while the planning target volume-to-breast ratio was associated with higher ipsilateral breast dose.
Early stereotactic radiotherapy was associated with longer progression-free survival in pancreatic cancer
Adding early stereotactic body radiotherapy to neoadjuvant chemoimmunotherapy was associated with median progression-free survival of 12.5 versus 6.6 months.
Regional lymph node irradiation altered immune responses after sinonasal stereotactic radiotherapy in dogs
Regional lymph node irradiation was linked to attenuated local cytokine shifts and nodal damage and cell-death signatures after sinonasal stereotactic radiotherapy.
Oxygen ions produced greater pancreatic cancer cell killing than carbon ions and photons
Oxygen-ion irradiation showed higher biological effectiveness and more persistent DNA damage than carbon ions or photons in pancreatic cancer cells.
Split inhale–exhale planning reduced rib dose in lung stereotactic body radiotherapy
Splitting eight fractions between inhale and exhale breath-holds reduced maximum rib dose from 67.9 to 33.5 Gy without compromising target coverage.
Early diffusion changes precede brain lesions after proton therapy for low-grade glioma
Regional diffusion changes distinguished patients who developed contrast-enhancing brain lesions as early as six months after proton therapy.