CHAF1A promotes DNA repair and tumor radioresistance through RAD51 and KU70
CHAF1A supported homologous recombination and non-homologous end joining, while its depletion increased radiosensitivity in xenograft models.
Tag
preliminary
Chemoradiotherapy and immunoradiotherapy reshape distinct esophageal cancer microenvironment programs
Chemoradiotherapy suppressed LAMC2–macrophage signalling, while immunoradiotherapy enriched CCL5-positive CD8 T cells in preclinical esophageal squamous-cell carcinoma models.
Interpretable AI separated three-year anal cancer relapse risk after chemoradiotherapy
An explainable model separated three-year local relapse rates of 11% versus 39%, but lacks independent external validation.
Radiotherapy-specific nutrition screening tool showed high agreement with established assessments
NRS-RT showed 92.9% sensitivity and 97.2% specificity versus NRS-2002, but requires external validation before clinical adoption.
Simulation-free adaptive lung SBRT was feasible in the ONE STOP pilot
Eight of ten patients completed simulation-free single-fraction adaptive lung SBRT, with treatment taking a median 72 minutes.
LncDNAH5 linked a prostate radiotoxicity risk variant to altered DNA repair
The rs7720298 risk allele increased LncDNAH5 expression, promoting TP53BP1 degradation and worsening radiation-induced bladder injury in mice.
Hybrid CT features predicted symptomatic pneumonitis after locally advanced NSCLC radiotherapy
A hybrid peri-tumoural CT model achieved an external AUC of 0.828 for predicting grade 2 or higher radiation pneumonitis.
Preoperative radiotherapy accompanied functional improvement after revision surgery for knee arthrofibrosis
Range of motion improved by nearly 29° after revision arthroplasty preceded by 8 Gy, with parallel improvements in pain and function.
SBRT controlled bone lesions but rarely delayed systemic therapy in bladder cancer
Two-year local control reached 88%, but median progression-free survival was 5.8 months and systemic treatment changed after 4.4 months.
Bladder dose escalation reduced invasive recurrence without increasing toxicity
Two-year invasive recurrence fell from 27.5% to 5.5% with dose escalation, without higher grade 2 or greater toxicity.
High-dose chemotherapy was linked to radiographic brain injury after proton therapy for medulloblastoma
Radiographic brain injury occurred in 16% of children, all asymptomatic; every affected patient had received high-dose chemotherapy.
Tetrandrine trial will test prevention of lung injury during esophageal chemoradiotherapy
A randomized phase II trial will test whether intravenous tetrandrine reduces grade 2 or higher lung injury from 25% to 10%.
FLASH altered early molecular responses without improving breast cell survival
Electron FLASH changed DNA-damage, transcriptomic, cytokine, and microtubule responses but did not alter clonogenic survival under normoxic conditions.
TFDP2-PDK3 metabolic signaling drove nasopharyngeal carcinoma radioresistance
TFDP2 activated PDK3, shifted nasopharyngeal carcinoma cells toward glycolysis, and reduced radiation response in cellular and xenograft models.
Early ventilation changes predicted end-of-treatment lung function after radiotherapy
Early-treatment ventilation direction persisted to treatment completion in most photon- and proton-treated patients, with the prediction model explaining 89% of variation.