Deep-learning nomogram reproduced 3D treated volume for prostate HDR brachytherapy QA
A 3D deep-learning nomogram predicted the clinical prescription isodose with high spatial agreement, adding geometry-aware verification to post-plan QA.
Tag
prostate
MRI-derived oxygen extraction fell progressively during prostate MR-guided SBRT
Relative oxygen extraction declined across irradiated prostate and tumor tissue during five-fraction MRgSBRT, with the largest early changes.
Repeated TURP predicted late urinary toxicity more strongly than focal prostate dose escalation
After prior TURP, focal SIB was not significantly associated with severe late GU toxicity, while repeated TURP consistently identified higher-risk patients.
Prostate motion during online adaptation supports routine verification before treatment
Across 1,378 adaptive fractions, 4.6% had shifts above 6 mm and longer adaptation times were linked to greater prostate displacement.
Salvage HDR brachytherapy delayed systemic therapy after isolated seminal vesicle recurrence
In 22 patients, salvage HDR brachytherapy produced 40.5% five-year relapse-free survival but 18% developed grade ≥3 GU toxicity.
Neoadjuvant ADT obscured 40% of MRI-visible prostate lesions before focal boost
After neoadjuvant ADT, 40% of MRI-visible prostate lesions disappeared and remaining lesions shrank substantially more than the prostate gland.
Post-testosterone recovery PSA slope tracked progression but not metastatic risk
Faster PSA rise after testosterone recovery tracked progression, but associations with distant metastasis were inconsistent and too imprecise for clinical inference.
Higher HDR prostate D90 did not improve long-term biochemical control once coverage was adequate
Across 286 HDR monotherapy patients, higher EQD2 D90 was not associated with biochemical control or overall survival.
Single-fraction 15 Gy HDR boost achieved 94% six-year biochemical control in localized prostate cancer
In 607 predominantly high-risk patients, 15 Gy HDR boost plus EBRT produced durable six-year disease control with low severe late toxicity.
Motorized sagittal 3D ultrasound reduced scan variability in prostate HDR brachytherapy
Motorized probe rotation improved sagittal 3D ultrasound consistency and eliminated significant inter-operator variability seen with manual acquisition.
Daily online adaptation reduced acute GI toxicity during hypofractionated prostate radiotherapy
Grade ≥2 GI toxicity was 14% with oART versus 45% with IGRT, with better preservation of several HRQoL domains.
AI detected subtle temporal changes in routine prostate MR-Linac images
A deep-learning model ordered first-to-last fraction images with 95% accuracy, while smaller longitudinal changes were associated with later biochemical recurrence.
Focal lumbosacral plexus hotspots may contribute to severe toxicity after prostate radiotherapy
Two prostate RT cases suggest that focal lumbosacral plexus hotspots, particularly near 70 Gy, may contribute to severe neurologic toxicity.
Endorectal balloon enabled 78 Gy salvage boost for prostate-bed recurrence
In one macroscopic recurrence abutting rectum, an endorectal balloon reduced rectal V75 from 24.6% to 8.6%, enabling a 78 Gy boost.
Baseline urinary symptoms predicted late GU toxicity after hypofractionated prostate RT
Each one-point increase in baseline IPSS independently increased the odds of late grade ≥2 GU toxicity by 11%.