Reinforcement learning adapted proton spot delivery across respiratory phases
Patient-specific reinforcement learning improved moving-target coverage over static GTV plans while reducing some normal-tissue exposure compared with ITV planning.
Tag
Protons
GPU dose engine calculated MRI-guided proton plans within 14 seconds
gPRIDE closely matched Monte Carlo calculations for most anatomies and completed MRI-guided proton dose calculations within 13.7 seconds.
Gold nanoparticles increased proton radiosensitivity without a clear size-dependent effect
Gold nanoparticles increased proton-induced clonogenic killing from 4 Gy onward, with similar sensitization using 20- and 50-nm particles.
RadComp protons lowered mean cardiac dose without improving early cardiac-related quality of life
Protons substantially reduced mean cardiac exposure, but no cardiac dose metric predicted patient-reported symptoms during the first six months.
Proton therapy reduced estimated immune-cell dose in postoperative esophageal radiotherapy
Estimated immune-cell dose predicted lymphocyte decline and was substantially lower with proton plans, particularly spot-scanning proton arc therapy.
Bragg peak proton FLASH matched CyberKnife plans and cut beam delivery to seconds
In 10 recurrent glioblastoma replans, Bragg peak proton FLASH improved conformity and reduced estimated beam delivery from approximately 17 minutes to under two seconds.
Robust IMPT modestly reduced organ-at-risk dose in five-fraction prostate proton therapy
SFUD and robust IMPT maintained target coverage under uncertainty, while IMPT modestly reduced rectal and bladder dose.
Spine proton ablative radiotherapy achieved 74% two-year local control in selected patients
Spine proton ablative radiotherapy achieved 74% local control at one and two years, with no radiation myelopathy in a reirradiation-enriched cohort.
Fraction 15 was optimal for one-time offline replanning in head and neck proton therapy
A single offline replan at fraction 15 captured most achievable dosimetric benefit in simulated head and neck proton therapy.
Surface-contacted 3D bolus plus MLC reduced proton PBS lateral penumbra
Surface-contacted 3D boluses generally narrowed lateral penumbra and reduced surrounding dose versus a nozzle-mounted range shifter in proton PBS.
Single-field optimization improved proton LATTICE motion robustness
Single-field optimization improved proton LATTICE motion robustness
Pencil-beam scanning proton re-irradiation showed low acute toxicity in recurrent head and neck cancer
Pencil-beam scanning proton re-irradiation achieved 17.2-month median survival with 7.7% grade 3 or higher oral mucositis.
SMART-BRAIN enabled proton-based non-target brain sparing in medulloblastoma planning
SMART-BRAIN proton planning spared portions of non-target brain while maintaining target coverage in five medulloblastoma cases.
Dose-dependent linear energy transfer constraints supported proton toxicity interpretation
Dose-dependent linear energy transfer constraints aligned with published proton toxicity data better than fixed threshold approaches.
Upright computed tomography showed stable numbers for proton therapy planning
Upright computed tomography showed stable computed tomography numbers and greater than 99% proton dose gamma agreement versus conventional computed tomography.