Endorectal balloon enabled 78 Gy salvage boost for prostate-bed recurrence
In one macroscopic recurrence abutting rectum, an endorectal balloon reduced rectal V75 from 24.6% to 8.6%, enabling a 78 Gy boost.
Tag
salvage
PET-directed nodal RT plus temporary ADT showed durable 10-year prostate cancer outcomes
PET-directed elective nodal RT plus temporary ADT yielded 77% 10-year overall survival with low grade 3 GU and GI toxicity.
Daily MR-guided salvage radiotherapy showed low severe toxicity after prostatectomy
Daily adaptive salvage radiotherapy produced 6% new grade ≥2 urinary toxicity at 12 months in a prospective 51-patient cohort.
Salvage HDR brachytherapy had low severe toxicity but limited five-year biochemical control
Five-year PSA progression-free survival was 24.8% after two-fraction salvage HDR brachytherapy without androgen deprivation, despite low severe toxicity.
Most salvage prostate radiotherapy plans met SPPORT and RADICALS-HD dose constraints
Most multicenter salvage prostate radiotherapy plans met SPPORT and RADICALS-HD organ constraints, with smaller bladder volumes linked to more violations.
Daily adaptation improved target coverage and rectal sparing in postoperative prostate radiotherapy
Daily adaptation increased prostate-bed coverage from 92.1% to 98.5% and reduced high-dose rectal exposure during hypofractionated salvage radiotherapy.
Consolidative and salvage primary-tumour SABR showed similar outcomes in stage IV NSCLC
Primary-tumour SABR before progression or at oligoprogression produced similar survival and pneumonitis rates in selected patients with stage IV NSCLC.
SPPORT intensification did not worsen long-term quality of life
Short-term androgen deprivation impaired early sexual and hormonal quality of life, but treatment-arm differences were not clinically significant at five years.