Heterogeneous EclipseRT plus PD-1 therapy was feasible in nine bulky NSCLC patients
EclipseRT plus PD-1 blockade produced five responses among nine bulky NSCLC patients without grade ≥3 treatment-related toxicity.
Tag
spatially-fractionated
LET-optimized proton arc planning more than doubled the lattice peak-to-valley dose ratio
PATLESL increased lattice peak-to-valley dose ratio from 16.9 to 41.9 while reducing spot number and delivery time.
Minibeam radiotherapy achieved 92% one-year local control in refractory superficial tumors
In the first clinical minibeam series, 86% had symptomatic improvement and one-year local control reached 92% with minibeam treatment alone.
VMAT lattice radiotherapy produced 65% median shrinkage in bulky hepatocellular carcinoma
Twelve VMAT lattice courses produced 65% median tumor shrinkage and no local progression during short follow-up in bulky hepatocellular carcinoma.
VMAT lattice radiotherapy on standard linacs provided early palliation in bulky tumors
In eight bulky tumor sites, flattening-filter VMAT lattice radiotherapy produced 75% symptom relief with no grade 3 or higher acute toxicity.
Photon minibeams enable denser LATTICE patterns in small tumors
Mini-LATTICE created more compact high-dose vertices and greater peak-to-valley separation than conventional LATTICE across six planning cases.
Automated lattice radiotherapy evaluation cut analysis time nearly eightfold
An Eclipse-based tool reduced lattice plan evaluation from 15.4 to 2.0 minutes while maintaining close agreement with manual measurements.
Single-field optimization improved proton LATTICE motion robustness
Single-field optimization improved proton LATTICE motion robustness
VMAT lattice SFRT was deliverable across Edge and Halcyon linacs
VMAT-based lattice SFRT achieved cross-platform deliverability with gamma pass rates above 90% and preserved peak-to-valley dose ratios.