TBI conditioning outcomes depend on platform and chemotherapy—not radiation dose alone
This review argues against a universal TBI dose, emphasizing conditioning intensity, chemotherapy backbone, disease biology and patient fitness.
Tag
toxicity
3D-printed oral stents were associated with less toxicity after nasopharyngeal radiotherapy
Patient-specific stents improved tongue and parotid stability and were associated with substantially less hearing loss, dysphagia and dysgeusia.
S100A8/A9 blockade improved survival after abdominal irradiation in mice
Paquinimod blockade of S100A8/A9 improved survival, intestinal regeneration and barrier recovery after abdominal irradiation in preclinical models.
Minibeam radiotherapy achieved 92% one-year local control in refractory superficial tumors
In the first clinical minibeam series, 86% had symptomatic improvement and one-year local control reached 92% with minibeam treatment alone.
Three clinical variables predicted moderate-to-severe esophagitis during esophageal cancer radiotherapy
Tumor location, hypertension and albumin predicted moderate-to-severe acute esophagitis with an internally validated AUC of 0.816.
Bullous pemphigoid developed during breast radiotherapy with concurrent pembrolizumab
Bullous pemphigoid emerged after seven radiotherapy fractions during pembrolizumab, spreading beyond the treatment field and ultimately preventing completion of both therapies.
Bowel dose predicted acute diarrhea after both RAPIDO neoadjuvant strategies
Larger irradiated bowel volumes predicted acute diarrhea after both short-course total neoadjuvant treatment and chemoradiation, although discrimination was modest.
Retroverted uterus altered cervical brachytherapy dosimetry without worsening disease control
Retroverted uterine position increased rectal and bowel dose during cervical brachytherapy, but survival, recurrence and severe toxicity remained comparable.
Clinicians disagreed substantially on maximum acute toxicity during head and neck radiotherapy
Two blinded oncologists often assigned different peak toxicity grades, including grade 3 mucositis rates of 40.5% versus 17.6%.
LncDNAH5 linked a prostate radiotoxicity risk variant to altered DNA repair
The rs7720298 risk allele increased LncDNAH5 expression, promoting TP53BP1 degradation and worsening radiation-induced bladder injury in mice.
Pelvic bone marrow dose predicted hematologic toxicity during rectal chemoradiotherapy
Mean pelvic marrow dose above approximately 24 Gy and V40 above 13% identified higher hematologic toxicity risk during rectal chemoradiotherapy.
High-density bolus provided accurate superficial photon dose when air gaps were minimized
A 1 cm high-density bolus overcame 6 MV photon build-up, but a 2 cm air gap reduced small-field skin dose by 21%.
Pelvic insufficiency fractures affected nearly one-third after gynecologic IMRT
Pelvic insufficiency fractures occurred in 29.2% of patients, with postmenopause and elevated baseline t-PINP independently predicting risk.
High-dose chemotherapy was linked to radiographic brain injury after proton therapy for medulloblastoma
Radiographic brain injury occurred in 16% of children, all asymptomatic; every affected patient had received high-dose chemotherapy.
Concurrent olaparib increased severe dermatitis during radiotherapy for inflammatory breast cancer
Adding low-dose olaparib increased grade 3 dermatitis from 5.5% to 24.7% during postmastectomy radiotherapy for inflammatory breast cancer.