Head and neck radiotherapy worsens long-term oral health despite structured dental follow-up
After head and neck RT, 43% of patients lost teeth and higher oral cavity dose was associated with tooth loss.
Tag
toxicity
CTCAE v6.0 grading varied across identical gynecologic radiotherapy toxicity cases
In a small ESTRO poll, subjective and lower-grade adverse events showed substantial disagreement despite shared CTCAE v6.0 definitions.
Focal lumbosacral plexus hotspots may contribute to severe toxicity after prostate radiotherapy
Two prostate RT cases suggest that focal lumbosacral plexus hotspots, particularly near 70 Gy, may contribute to severe neurologic toxicity.
Pre-RT cachexia strongly predicted treatment discontinuation in head and neck cancer
Treatment discontinuation was 25.0% with pre-RT cachexia versus 4.6% without, with approximately sixfold higher adjusted odds.
Clinicians underestimated urinary and bowel symptoms after prostate radiotherapy
HYPO-RT-PC showed persistently poor agreement between patient- and clinician-reported toxicity, particularly for urinary and bowel symptoms.
Longer palliative RT courses were associated with substantially more lymphopenia
Compared with 8 Gy in one fraction, five- and ten-fraction regimens were associated with approximately two- and threefold higher odds of lymphopenia.
Machine learning showed moderate external prediction of hypothyroidism after head and neck radiotherapy
Random forest reached external AUC 0.769 for 12-month radiation-induced hypothyroidism, but calibration and clinical utility weakened outside the development center.
Treatment interruptions were associated with poorer early outcomes during lung cancer radiotherapy
Unplanned radiotherapy interruptions occurred in 35% and were associated with lower response, more toxicity and markedly worse six-month survival.
Baseline lymphocyte count predicted severe lymphopenia better than dosimetry in rectal cancer
Severe lymphopenia occurred in 44%, while baseline and week-2 lymphocyte counts outperformed 600 dosimetric variables for risk prediction.
Twenty-fraction head and neck radiotherapy was feasible in older and comorbid patients
Ninety-five percent completed 55 Gy in 20 fractions, with encouraging outcomes in early p16-positive oropharyngeal cancer despite substantial acute toxicity.
FLASH proton therapy preserved ocular function without reducing short-term tumor control
FLASH protons largely preserved ocular structure and retinal function after 24 Gy while maintaining short-term tumor control in mice.
Hybrid FLASH preserved normal-tissue sparing when the ultra-high-rate dose remained high
Hybrid ultra-high and conventional dose-rate irradiation retained FLASH sparing in mice, but protection diminished as the ultra-high-rate dose contribution decreased.
Lithium mouthwash reduced severe oral mucositis during head and neck radiotherapy
Lithium mouthwash reduced severe oral mucositis from 52.1% to 34.2% in a randomized phase II head and neck radiotherapy trial.
REQUITE revealed persistent toxicity and sex-specific symptom patterns after lung radiotherapy
Prospective REQUITE data showed substantial pulmonary toxicity after lung radiotherapy, with several sex-specific differences in symptoms and recovery.
TBI conditioning outcomes depend on platform and chemotherapy—not radiation dose alone
This review argues against a universal TBI dose, emphasizing conditioning intensity, chemotherapy backbone, disease biology and patient fitness.