Proton hemithoracic irradiation achieved major normal-tissue sparing with limited severe pneumonitis
Proton IMPRINT kept contralateral lung mean dose at 0.3 Gy, with grade 3 pneumonitis occurring in 6% of patients.
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Proton hypofractionation achieved durable control in heavily reirradiated spine metastases
Proton hypofractionation produced 10% one-year local failure despite extensive prior irradiation, with grade 3 toxicity confined to multiply reirradiated patients.
Sexual inactivity and dyspareunia remained common after cervical radio(chemo)therapy
Sexual inactivity reached 49% and dyspareunia 54% after cervical radio(chemo)therapy, with fatigue central to broader survivorship impairment.
KRAS mutation did not worsen intracranial control after SRS for NSCLC brain metastases
KRAS-mutant and wild-type NSCLC showed similar intracranial control after SRS, while higher radiation dose predicted better outcomes.
Food insecurity predicted markedly worse survival after comprehensive breast nodal irradiation
Five-year survival was 74.9% versus 90.2% for patients living in food-insecure versus other areas despite similar cancer treatment.
Multimodal AI proposed major surveillance reduction after stage II NPC
External validation achieved AUC 0.986, while modeled risk-adapted surveillance reduced visits by 90.0–98.5% and identified every observed failure.
Higher tumor LET predicted better local control after carbon-ion NPC reirradiation
Recurrent NPC with GTV LETd99 ≥39.4 keV/μm had 94.4% versus 65.3% two-year local control after carbon-ion reirradiation.
Clinical-genomic models improved prediction of late breast radiotherapy toxicity
Adding SNP data increased arm-lymphedema prediction AUC from 0.78 to 0.93 in the multicenter REQUITE cohort.
Radiotherapy achieved 98% local control in head and neck paragangliomas
Protons, SRS and IMRT produced 98% overall local control without grade 3–5 toxicity in 54 paragangliomas.
Non-endemic nasopharyngeal cancer showed similar locoregional and distant failure rates
Five-year overall survival was 71%, with most distant failures occurring during the first three years after treatment.
Early PSA-density kinetics after prostate SABR identified patients at high recurrence risk
Combining ISUP grade with 3–6-month PSA-density kinetics separated seven-year biochemical control at 93.5% versus 53.4% after SABR without ADT.
Extensive coronary calcification on breast RT planning CT predicted ischemic heart disease
All six ischemic events occurred in patients with extensive coronary calcification on breast RT simulation CT, versus none with absent or mild calcification.
Updated level IVa contouring reduced predicted hypothyroidism risk in nasopharyngeal cancer
Updated level IVa delineation reduced predicted hypothyroidism from 43.9% to 34.9% without compromising target coverage.
Simulation-free vaginal brachytherapy produced low five-year recurrence in high-intermediate-risk endometrial cancer
Five-year vaginal recurrence was 3.6% without verification imaging, versus 1.6% reported in the separate PORTEC-4a brachytherapy cohort.
International survey identifies culture and leadership as central radiation oncology retention drivers
Across 53 countries, workforce retention was shaped by culture, leadership, career development, resource strain, recognition and burnout.