Feature selection strongly affected radiomics prediction of xerostomia after head-and-neck RT
T1 MRI with R-MRmr reached AUC 0.96 for early xerostomia, while late sticky-saliva prediction remained substantially weaker.
Tag
xerostomia
DW-MRI-guided parotid sparing showed exploratory acute toxicity and quality-of-life signals
Lower dose to diffusion-defined contralateral parotid subvolumes showed early associations with xerostomia-related outcomes, but most dose–toxicity relationships were not significant.
Contralateral parotid mean dose remains the strongest xerostomia predictor in head and neck RT
Contemporary evidence supports contralateral parotid mean dose as the most robust xerostomia predictor, with risk rising around 24–26 Gy.
Radiomic shape features improved xerostomia prediction after nasopharyngeal radiotherapy
Adding parotid–target overlap shape features improved moderate-to-severe xerostomia prediction from AUC 0.66 to 0.78.
Submandibular gland transfer reduced salivary-gland dose by 12 Gy during proton therapy
Surgical transfer reduced contralateral submandibular mean dose by approximately 12 Gy during bilateral IMPT without compromising target coverage.