Day-before-surgery radiotherapy matched diclofenac for heterotopic ossification prevention
A single 7 Gy fraction delivered 20–28 hours before hip arthroplasty produced similar heterotopic ossification rates to postoperative diclofenac.
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Retroverted uterus altered cervical brachytherapy dosimetry without worsening disease control
Retroverted uterine position increased rectal and bowel dose during cervical brachytherapy, but survival, recurrence and severe toxicity remained comparable.
Simulation-free CBCT workflow enabled urgent radiotherapy within about two hours
The OSCAR workflow delivered the first urgent or palliative fraction without planning CT in approximately 1 hour 50 minutes.
Real-world brain MR-only implementation exposed frequent synthetic CT artifacts
Synthetic CT artifacts were common during brain MR-only implementation, highlighting workflow QA and patient-selection issues not captured by controlled validation.
Commercial AI synthetic CT showed good soft-tissue agreement but important high-density failures
AI synthetic CT preserved soft-tissue HU and geometry well, while bone, air interfaces and implanted devices remained important failure modes.
Radiotherapy-specific nutrition screening tool showed high agreement with established assessments
NRS-RT showed 92.9% sensitivity and 97.2% specificity versus NRS-2002, but requires external validation before clinical adoption.
Twenty-two Gy SRS was associated with better brain metastasis control than 20 Gy
Single-fraction 22 Gy SRS achieved higher one-year local control than 20 Gy, although retrospective dose selection creates important confounding.
Carboplatin-paclitaxel showed comparable outcomes in cisplatin-ineligible head and neck cancer
Retrospective outcomes with carboplatin-paclitaxel were not significantly different from cisplatin, supporting its use when cisplatin is contraindicated.
Photon minibeams enable denser LATTICE patterns in small tumors
Mini-LATTICE created more compact high-dose vertices and greater peak-to-valley separation than conventional LATTICE across six planning cases.
AI-derived LAD dose reproduced survival stratification in RTOG 0617
Automated LAD contours reproduced the association between coronary dose and survival in 460 stage III NSCLC patients, although performance varied by model.
Simulation-free adaptive lung SBRT was feasible in the ONE STOP pilot
Eight of ten patients completed simulation-free single-fraction adaptive lung SBRT, with treatment taking a median 72 minutes.
Pneumatic compression and usual care provide similar long-term control of head and neck lymphedema
Six-month symptom control was similar with advanced pneumatic compression and usual care, although some clinician-rated lymphedema measures favored compression.
Deep learning-enhanced registration halves contouring time in daily adaptive prostate MRgRT
A hybrid deep learning–registration workflow reduced median daily prostate MRgRT contouring time from 7.8 to 3.1 minutes while maintaining high contour agreement.
Training-free MRI tracking achieved submillimetre motion accuracy in liver metastases
ETLD tracked 106,000 cine-MRI frames with submillimetre error, while integrated segmentation achieved a mean global Dice score of 87.7%.
Clinicians disagreed substantially on maximum acute toxicity during head and neck radiotherapy
Two blinded oncologists often assigned different peak toxicity grades, including grade 3 mucositis rates of 40.5% versus 17.6%.