Interim CT shrinkage and FDG-PET uptake predicted head and neck outcomes
Low CT tumour shrinkage strongly predicted poorer locoregional control, while high interim FDG-PET uptake predicted both poorer control and survival.
Latest
LncDNAH5 linked a prostate radiotoxicity risk variant to altered DNA repair
The rs7720298 risk allele increased LncDNAH5 expression, promoting TP53BP1 degradation and worsening radiation-induced bladder injury in mice.
Pelvic bone marrow dose predicted hematologic toxicity during rectal chemoradiotherapy
Mean pelvic marrow dose above approximately 24 Gy and V40 above 13% identified higher hematologic toxicity risk during rectal chemoradiotherapy.
Deep learning reduced pediatric craniospinal target contouring from eight hours to 30 minutes
Automated pediatric CSI contours achieved a mean Dice score of 0.959 and reduced target-delineation time from approximately eight hours to 30 minutes.
Deformable registration substantially changed cumulative dose estimates in stereotactic re-irradiation
DIR reduced estimated liver maximum dose from 123.8 to 83.2 Gy, but accuracy deteriorated markedly for bowel and stomach.
Hybrid CT features predicted symptomatic pneumonitis after locally advanced NSCLC radiotherapy
A hybrid peri-tumoural CT model achieved an external AUC of 0.828 for predicting grade 2 or higher radiation pneumonitis.
An LLM agent generated head and neck IMRT plans comparable to clinical plans
Reference-free LLM planning improved hotspot control and boost-target conformity while maintaining organ-at-risk sparing comparable to clinical plans.
Two-dimensional TCP modeling linked lung tumour control mainly to radiosensitivity heterogeneity
Inter-patient radiosensitivity explained 85–97% of modeled TCP steepness, while uncertainty in delivered dose exceeded uncertainty in local-control estimates.
Expiratory-phase CBCT reduced respiratory blurring during pancreatic SBRT
Repeated end-expiratory breath-hold CBCT achieved boundary sharpness statistically equivalent to daily CT in 10 pancreatic SBRT patients.
High-density shielding materials reduced modeled radiotherapy vault footprint by up to 34%
Alternative shielding materials reduced modeled linac vault area by 17–34% while remaining below the NCRP controlled-area dose goal.
Unshielded SunSILICON detector performed reliably for small-field photon dosimetry
The unshielded SunSILICON detector required only modest corrections in small fields, while the shielded version became unreliable below approximately 2 cm.
Vergence-based planning predicted major astigmatism reduction after toric lens realignment
Model-predicted 16–18° lens rotations reduced residual refractive cylinder by 1.7–2.4 D across four representative clinical scenarios.
Radiotherapy 3D printing needs standardized quality assurance across institutions
Inter-centre material variability supports shared QA datasets and standardized acceptance criteria for clinical radiotherapy 3D printing.
Euro-EWING99 long-term analysis defines outcomes in 3,395 patients with Ewing sarcoma
Five-year progression-free and overall survival were 55.4% and 64.6%, with metastatic status and histologic response remaining major prognostic factors.
Surface monitoring detected clinically relevant motion in head and neck radiotherapy
SGRT triggered verification in 15% of head and neck fractions, but almost half of alerts were not confirmed on X-ray imaging.