Omitted guideline-recommended sectors drove local failure after sacral SBRT
Seventy-three percent of failures after nonadherent sacral contouring involved sectors that guidelines recommended including in the clinical target volume.
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RT-Optimus replaces maximum tolerated dose with an optimal combination regimen
Experts propose selecting radiotherapy–drug regimens using efficacy, scheduling, late toxicity, biomarkers, and patient-reported outcomes rather than maximum tolerated dose alone.
Patient-informed design supported rapid and representative COMPPARE trial accrual
COMPPARE enrolled 2,524 patients from 51 institutions in 52 months, with Black participation reaching 16% of the cohort.
Online proton adaptation improved dosimetry but required about one hour per fraction
Adaptation would have improved organ sparing or target coverage in 46% of fractions, with a median workflow time of 61.9 minutes.
Carbon-ion Gy(RBE) values are not directly interchangeable between planning systems
Different carbon-ion RBE models can assign substantially different biological doses to the same absorbed-dose distribution, requiring context-specific translation.
Submillimetre MLC errors substantially altered HyperArc brain metastasis dose
A 1 mm symmetric MLC closing reduced minimum GTV dose by 25%, while translations caused cumulative target undercoverage.
High-density bolus provided accurate superficial photon dose when air gaps were minimized
A 1 cm high-density bolus overcame 6 MV photon build-up, but a 2 cm air gap reduced small-field skin dose by 21%.
TLD-100 response varied systematically with synchrotron proton dose rate
TLD-100 over-responded below 7 Gy/s and under-responded above 300 Gy/s, despite remaining dose-independent from 3 to 18 Gy.
T1-weighted MRI plus CT best automated EPTN neuro-oncology organ contouring
A dual-input MRI–CT model segmented 25 neurological organs with a median Dice score of 0.80 and surface Dice of 0.84.
Pelvic insufficiency fractures affected nearly one-third after gynecologic IMRT
Pelvic insufficiency fractures occurred in 29.2% of patients, with postmenopause and elevated baseline t-PINP independently predicting risk.
Sleep adjustment avoided sedation in most pediatric radiotherapy fractions
A structured sleep protocol enabled sedation-free delivery in 96.4% of radiotherapy fractions among children younger than four years.
Metabolic tumour volume refined treatment selection in early NK/T-cell lymphom
An MTV threshold of 50 mL identified patients with poorer survival who appeared to benefit from combined-modality treatment.
Protons produced greater subclinical lung changes after breast nodal irradiation
Proton therapy produced greater CT-detected lung changes than photons despite lower lung dose and no increase in clinical pulmonary toxicity.
Bladder dose escalation reduced invasive recurrence without increasing toxicity
Two-year invasive recurrence fell from 27.5% to 5.5% with dose escalation, without higher grade 2 or greater toxicity.
Experts reached limited consensus on prostate GTV contouring and micro-boosting
Only 33% of statements reached consensus, but experts agreed on multimodality imaging, eligible lesions, and daily image guidance.