Adaptive MR-guided prostate SBRT showed low toxicity after the early treatment peak
Grade ≥2 urinary toxicity fell from 22% at two weeks to 3% at six months, with almost no clinically significant bowel toxicity.
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Prostate radiotherapy biomarker review found timing more limiting than assay choice
None of four selected blood-biomarker domains currently supports treatment personalization, and sampling schedules frequently failed to match expected biological kinetics.
Virtual reality increased confidence after HDR prostate brachytherapy training
Brief virtual-reality training increased self-reported procedural confidence, but knowledge, technical skill, retention, and clinical performance were not tested.
Protons reduced spinal cord and bowel dose in single-fraction spine SBRT plans
Proton plans preserved 20-Gy target coverage while reducing spinal cord, oesophageal, lung, and bowel dose compared with photon VMAT.
Combined dose–LET model predicted temporal lobe necrosis after skull-base proton therapy
Temporal lobe volumes receiving high dose or moderate dose with high LET jointly predicted grade 2 or higher necrosis.
BARitOne will escalate oropharyngeal dose only for MRI-defined non-responders
BARitOne uses on-treatment diffusion MRI to increase gross tumour dose from 65 to 73 Gy only in predicted non-responders.
Five-fraction MR-guided prostate-bed radiotherapy showed low early toxicity
No grade 3 toxicity occurred after five-fraction MR-guided salvage radiotherapy, while urinary and bowel quality-of-life scores remained stable.
Anal cancer radiotherapy–immunotherapy trials remain too heterogeneous for direct comparison
Twelve trials used 14 immunotherapy regimens with major differences in eligibility, radiotherapy, chemotherapy, endpoints, and translational analysis.
Prostate radiotherapy modestly increased secondary pelvic cancer incidence over long follow-up
Randomized evidence suggested a 4.5-point increase in second-cancer incidence, while excess mortality from other cancers was substantially smaller.
Abdominal airbag matched plate compression but increased lateral setup error
Airbag compression reduced upper-abdominal respiratory motion comparably to a rigid plate but produced larger left–right setup errors.
Immunotherapy-based TNT eliminated nodal disease in ypT0–1 rectal tumours
No positive lymph nodes were found in ypT0–1 tumours after immunotherapy-based TNT, supporting further study of local excision.
ECHO automated lung planning across seven fractionation schedules in routine practice
ECHO generated consistent lung IMRT and VMAT plans while reducing active planner time by approximately 90 minutes per case.
Three-week locoregional breast radiotherapy was noninferior for arm lymphedema
40 Gy in 15 fractions did not increase three-year arm lymphedema or compromise recurrence and mortality outcomes compared with 50 Gy.
Oxaliplatin-based total neoadjuvant therapy improved three-year DFS in high-risk rectal cancer
Doublet total neoadjuvant therapy improved three-year disease-free survival, metastasis-free survival, and pathological complete response compared with conventional chemoradiotherapy.
AutoAdapt produced acceptable prostate MR-guided plans with minimal planner input
AI-generated constraints produced clinically acceptable adaptive prostate plans, although only seven of ten met every prespecified planning objective.