DEGRO supports ultrahypofractionation for low- to intermediate-risk prostate cancer, with comparable control but increased late genitourinary toxicity in selected patients.
PVC was detected in 37 of 72 HCC tumors and was associated with poorer response and progression-free survival after SBRT, immunotherapy, and bevacizumab.
Consolidation durvalumab after concurrent chemoradiotherapy halved the adjusted risk of progression or death at two years in real-world stage III NSCLC.
Surface-contacted 3D boluses generally narrowed lateral penumbra and reduced surrounding dose versus a nozzle-mounted range shifter in proton PBS.
After prostate and pelvic nodal SBRT, no grade ≥3 late GU or GI toxicity occurred among 101 patients with high-risk disease.
In 19 high-risk patients receiving 177Lu-PSMA-617, post-cycle 1 dosimetry changed management in 32%, prompting five activity reductions and one delay.
Symptomatic grade ≥2 cardiac toxicity occurred in 8% after central or ultracentral lung SBRT, typically developing more than one year after treatment.
Lower pretreatment microvascular health was associated with more acute toxicity overall, while disease-specific performance was strongest in breast cancer.
Nearly one-third of lung SBRT studies counted failures beyond the treated tumor as local events, limiting comparison of reported control rates.
In mice, FLASH reduced acute chemokine and later macrophage-associated transcription versus conventional irradiation, without significantly reducing collagen deposition.
Postoperative conventional radiotherapy caused fewer head-and-neck symptoms and dominated preoperative accelerated radiotherapy in the five-year cost-utility analysis.
Combined FDG-PET and multiparametric MRI achieved only modest pCR prediction after neoadjuvant chemoradiotherapy, with a cross-validated AUC of 0.65.
BiHU-GAN generated synthetic contrast and non-contrast CT with high contour agreement and at least 95% gamma pass rates at 2%/2 mm.
Once-weekly prostate-and-pelvis SBRT reduced acute gastrointestinal toxicity versus conventional IMRT without significantly increasing genitourinary toxicity.
Higher postoperative CTV minimum BED10 was associated with lower local failure after separation surgery and spine SBRT.