RapidPlan lung SBRT model used gEUD objectives for reproducible planning
A RapidPlan lung SBRT model generated clinically acceptable plans in 52% of validation cases on first optimization.
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Single-field optimization improved proton LATTICE motion robustness
Single-field optimization improved proton LATTICE motion robustness
Higher-BED palliative radiotherapy improved symptoms in rectal cancer
BED >37.5 Gy improved symptomatic control, while 6-month local control remained 46% in frail, elderly, or metastatic rectal cancer.
Carbon ion re-irradiation showed feasible salvage outcomes in recurrent pelvic sarcoma
High-dose carbon ion re-irradiation achieved 83.1% 3-year survival with no grade 4 toxicity in recurrent pelvic sarcoma.
CT-guided online adaptation improved prostate SBRT dosimetry
CT-guided online adaptive prostate SBRT was feasible, with adapted plans selected in 95% of fractions and dosimetric improvements in 85%.
Concurrent polatuzumab vedotin and radiotherapy showed no unexpected toxicity in B-cell lymphoma
Concurrent polatuzumab vedotin and radiotherapy was feasible in heavily pretreated aggressive B-cell lymphoma without unexpected acute or subacute toxicity.
Twice-weekly 28 Gy whole-breast irradiation showed low toxicity in early breast cancer
Twice-weekly 28 Gy in 5 fractions produced no grade 3 or higher toxicity and 98.8% excellent-to-good cosmesis at 1 year.
NEOTRAC shortened treatment duration without improving pCR in HER2-positive inoperable breast cancer
Concurrent neoadjuvant radiotherapy shortened treatment duration but did not improve pathological complete response or survival.
Timing shaped radiotherapy-immunotherapy synergy across mechanisms
This systematic review found that optimal radiotherapy-immunotherapy sequencing depends on the immune mechanism being targeted.
VMAT lattice SFRT was deliverable across Edge and Halcyon linacs
VMAT-based lattice SFRT achieved cross-platform deliverability with gamma pass rates above 90% and preserved peak-to-valley dose ratios.
MIM software accelerated sarcopenia screening during prostate radiotherapy planning
MIM-based skeletal muscle index measurement matched ImageJ while reducing processing time from 10 to 3.5 minutes.
Federated learning improved radiation pneumonitis prediction across lung cancer datasets
A center-specific federated learning model predicted grade 2 or higher radiation pneumonitis with stable cross-dataset performance.
Fat necrosis remained low after single-fraction stereotactic partial breast irradiation
Single-fraction GammaPod partial breast irradiation produced 12.1% fat necrosis and 4.1% symptomatic fat necrosis in a phase 2 trial.
Knowledge-based planning reduced organ-at-risk dose in head and neck and brain planning
RapidPlan reduced several organ-at-risk dose metrics while maintaining comparable target coverage in head and neck and brain radiotherapy planning.
Thoracic radiotherapy with atezolizumab increased toxicity in extensive-stage small cell lung cancer
TREASURE found no survival benefit and higher serious toxicity with thoracic radiotherapy added to atezolizumab maintenance.