Berberine increased radiation-induced DNA damage and tumor suppression in HNSCC models
Berberine enhanced radiation response in HNSCC models by increasing DNA damage and apoptosis while suppressing DNA repair and stemness pathways.
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Sexual inactivity and dyspareunia remained common after cervical radio(chemo)therapy
Sexual inactivity reached 49% and dyspareunia 54% after cervical radio(chemo)therapy, with fatigue central to broader survivorship impairment.
HyperSight CBCT approached simulation-CT dosimetry for offline adaptive breast radiotherapy
HyperSight reduced PTV dose-recalculation deviations versus Halcyon 3.1 while using a lower imaging dose in 12 breast radiotherapy patients.
Single-fraction lung SBRT achieved 100% estimated one-year local control in selected patients
Single-fraction SBRT achieved 100% estimated 12-month local control without grade ≥3 toxicity in a selected 49-patient cohort.
Maskless SGRT improved initial pelvic setup and shortened positioning time
Maskless SGRT reduced initial setup error and cut mean positioning time by about 29% compared with thermoplastic-mask alignment.
TBI conditioning outcomes depend on platform and chemotherapy—not radiation dose alone
This review argues against a universal TBI dose, emphasizing conditioning intensity, chemotherapy backbone, disease biology and patient fitness.
Neoadjuvant chemotherapy shifted HR+/HER2− breast tumors toward higher genomic radioresistance
RSI increased after neoadjuvant chemotherapy in 23 of 30 matched HR+/HER2− tumors, but implications for adjuvant radiation dose remain unproven.
No lung subregion strategy clearly improved radiation pneumonitis prediction
Whole-lung, physical-dose and BED3 models performed similarly externally, with the best complete-model AUC only 0.684 and inadequate calibration.
KRAS mutation did not worsen intracranial control after SRS for NSCLC brain metastases
KRAS-mutant and wild-type NSCLC showed similar intracranial control after SRS, while higher radiation dose predicted better outcomes.
Heterogeneous EclipseRT plus PD-1 therapy was feasible in nine bulky NSCLC patients
EclipseRT plus PD-1 blockade produced five responses among nine bulky NSCLC patients without grade ≥3 treatment-related toxicity.
Severe brainstem necrosis followed standard proton CSI in 22q11.2 deletion syndrome
A patient with 22q11.2 deletion developed refractory brainstem necrosis nine months after guideline-concordant proton craniospinal irradiation.
Structured cumulative-dose review triggered replanning in one-quarter of proton reirradiation cases
Voxel-wise cumulative EQD2 review prompted reoptimization in 25.5% of proton reirradiation courses and exposed frequent registration problems.
Modern proton breast radiotherapy offers cardiopulmonary sparing but randomized clinical benefit remains pending
Modern proton techniques reduce cardiopulmonary dose and can control skin exposure, while randomized cardiac and cancer-control endpoints remain pending.
Iodine-125 brachytherapy preserved lung function in high-risk NSCLC patients
CT-guided iodine-125 implantation achieved 60.7% one-year response without grade ≥3 pneumonitis in patients with severe pulmonary dysfunction.
Immune-rich rectal tumors responded better to neoadjuvant radiotherapy than stromal-rich tumors
Responsive rectal tumors showed greater cytotoxic immune infiltration, while poor responders were enriched for stromal, EMT and oncogenic pathways.