Overlap-adapted dose reduction lowered temporal lobe injury in T4 nasopharyngeal cancer
Reducing the PTV–temporal lobe overlap dose to 66 Gy lowered five-year radiographic temporal lobe injury from 36.2% to 23.2%.
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Persistent internal mammary nodes on MRI identified patients associated with benefit from boost
Internal mammary node boost was associated with better disease-free survival only when MRI showed residual nodal disease after neoadjuvant therapy.
Lithium mouthwash reduced severe oral mucositis during head and neck radiotherapy
Lithium mouthwash reduced severe oral mucositis from 52.1% to 34.2% in a randomized phase II head and neck radiotherapy trial.
Yttrium-90 radioembolization produced durable hepatic responses in SDH-deficient GIST
Yttrium-90 radioembolization achieved 67% objective response and 100% disease control in 12 patients with SDH-deficient GIST liver metastases.
Most salvage prostate radiotherapy plans met SPPORT and RADICALS-HD dose constraints
Most multicenter salvage prostate radiotherapy plans met SPPORT and RADICALS-HD organ constraints, with smaller bladder volumes linked to more violations.
Smaller sequential brachytherapy applicators improved dose uniformity on curved surfaces
Smaller modular superficial brachytherapy applicators and sequential placement substantially improved dose uniformity, especially for beta-emitting sources.
Deep learning proton plans were clinically accepted for all 78 oropharyngeal patients
All 78 deep learning-generated IMPT plans were clinically accepted, with comparable or lower organ doses than manual benchmark plans.
REQUITE revealed persistent toxicity and sex-specific symptom patterns after lung radiotherapy
Prospective REQUITE data showed substantial pulmonary toxicity after lung radiotherapy, with several sex-specific differences in symptoms and recovery.
Gamma Knife and LINAC radiosurgery produced similar vestibular schwannoma outcomes
Gamma Knife and LINAC radiosurgery produced similarly high control and low new neurologic symptoms in 85 vestibular schwannoma patients.
Causal modeling suggested elevated proton RBE for mandibular osteoradionecrosis
Causal modeling estimated mandibular proton RBE at 1.61, 1.30 and 1.13 at 40, 50 and 60 GyRBE, respectively
Age and comorbidity identified poor prognosis in elderly patients receiving esophageal chemoradiotherapy
Patients aged ≥75 years with CIRS-G ≥7 had median overall survival of 16 months after definitive chemoradiotherapy.
Early response-adapted TNT preserved the rectum in a minority of selected patients
Two-year sustained complete response was 36% after short-course RT and response-adapted FOLFOX4, while near-complete responses frequently regrew.
Proton hemithoracic irradiation achieved major normal-tissue sparing with limited severe pneumonitis
Proton IMPRINT kept contralateral lung mean dose at 0.3 Gy, with grade 3 pneumonitis occurring in 6% of patients.
Third-course reirradiation provided symptom relief in selected patients with progressive DIPG
Across 12 reported patients receiving at least three radiation courses for DIPG, median survival was 27 months with frequent symptomatic benefit.
Proton hypofractionation achieved durable control in heavily reirradiated spine metastases
Proton hypofractionation produced 10% one-year local failure despite extensive prior irradiation, with grade 3 toxicity confined to multiply reirradiated patients.