Metastasis-directed EBRT was feasible alongside Lu-PSMA-617 in metastatic prostate cancer
Among 88 patients receiving both treatments, PSA50 response was 55.7% and prior metastasis-directed EBRT did not increase hematologic toxicity.
Latest research
Search the archiveSmall photon fields reduced detected Cherenkov signal despite stable dose-linked production
Detected Cherenkov signal per dose fell sharply in small fields, driven mainly by optical transport rather than major changes in intrinsic Cherenkov production.
Integrated rapid palliative RT achieved fast treatment without a dedicated clinic
A routine departmental workflow delivered rapid palliative RT with a median 109-minute treatment process despite having no dedicated rapid-access clinic.
Five-fraction breast RT is established for WBI and APBI, while RNI evidence matures
Five-fraction RT is well supported for selected whole- and partial-breast treatment, while regional nodal and postmastectomy evidence remains less mature.
PET-directed nodal RT plus temporary ADT showed durable 10-year prostate cancer outcomes
PET-directed elective nodal RT plus temporary ADT yielded 77% 10-year overall survival with low grade 3 GU and GI toxicity.
Sinoatrial node dose was linked to early ECG abnormalities after breast IMRT
Higher sinoatrial node low-dose exposure independently tracked with new ECG abnormalities after postoperative breast IMRT in this exploratory retrospective cohort.
ASTRO guideline endorses trimodal therapy and 55 Gy in 20 fractions for bladder cancer
ASTRO recommends trimodal therapy as an alternative to cystectomy in selected muscle-invasive bladder cancer and supports 55 Gy in 20 fractions.
PSMA/MRI-guided prostate SABR with focal boost showed strong two-year imaging response
In ARGOS-CLIMBER, PSMA/MRI-guided five-fraction pelvic SABR produced a 67% PET complete response rate at two years with limited late GU toxicity.
Pretrained deep-learning IMPT planning transferred across centres with comparable plan quality
After two days of local configuration, a pretrained model generated oropharyngeal IMPT plans with overall quality comparable to manual planning.
Consensus QA improved target delineation for perihilar cholangiocarcinoma SBRT
Target Dice improved from 0.57 to 0.74 after consensus QA, although OAR constraints still limited PTV coverage in most plans.
Four-point symptom score identified radiation pneumonitis in older lung cancer patients
In POLCAR, a four-point symptom threshold detected seven of eight pneumonitis cases and achieved a 97% negative predictive value.
Hypofractionated proton re-irradiation remains promising but supported by limited evidence
Across 478 patients, hypofractionated proton re-irradiation showed encouraging site-specific outcomes, but heterogeneous retrospective evidence prevents firm conclusions on efficacy or safety.
Extensive keloids had high wound dehiscence after postoperative radiotherapy
Wound dehiscence occurred in 78% of extensively involved keloid sites versus 5% of simple lesions after surgery and postoperative RT.
Total laryngectomy improved local control over chemoradiotherapy in selected advanced laryngeal cancer
Surgery provided substantially better local control in T3–T4a N0–N1 laryngeal cancer, while disease-specific survival remained similar and CRT preserved laryngeal function in 79%.
Pre-RT cachexia strongly predicted treatment discontinuation in head and neck cancer
Treatment discontinuation was 25.0% with pre-RT cachexia versus 4.6% without, with approximately sixfold higher adjusted odds.