Carboplatin-paclitaxel showed comparable outcomes in cisplatin-ineligible head and neck cancer
Retrospective outcomes with carboplatin-paclitaxel were not significantly different from cisplatin, supporting its use when cisplatin is contraindicated.
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Photon minibeams enable denser LATTICE patterns in small tumors
Mini-LATTICE created more compact high-dose vertices and greater peak-to-valley separation than conventional LATTICE across six planning cases.
AI-derived LAD dose reproduced survival stratification in RTOG 0617
Automated LAD contours reproduced the association between coronary dose and survival in 460 stage III NSCLC patients, although performance varied by model.
Simulation-free adaptive lung SBRT was feasible in the ONE STOP pilot
Eight of ten patients completed simulation-free single-fraction adaptive lung SBRT, with treatment taking a median 72 minutes.
Pneumatic compression and usual care provide similar long-term control of head and neck lymphedema
Six-month symptom control was similar with advanced pneumatic compression and usual care, although some clinician-rated lymphedema measures favored compression.
Deep learning-enhanced registration halves contouring time in daily adaptive prostate MRgRT
A hybrid deep learning–registration workflow reduced median daily prostate MRgRT contouring time from 7.8 to 3.1 minutes while maintaining high contour agreement.
Training-free MRI tracking achieved submillimetre motion accuracy in liver metastases
ETLD tracked 106,000 cine-MRI frames with submillimetre error, while integrated segmentation achieved a mean global Dice score of 87.7%.
Clinicians disagreed substantially on maximum acute toxicity during head and neck radiotherapy
Two blinded oncologists often assigned different peak toxicity grades, including grade 3 mucositis rates of 40.5% versus 17.6%.
Interim CT shrinkage and FDG-PET uptake predicted head and neck outcomes
Low CT tumour shrinkage strongly predicted poorer locoregional control, while high interim FDG-PET uptake predicted both poorer control and survival.
LncDNAH5 linked a prostate radiotoxicity risk variant to altered DNA repair
The rs7720298 risk allele increased LncDNAH5 expression, promoting TP53BP1 degradation and worsening radiation-induced bladder injury in mice.
Pelvic bone marrow dose predicted hematologic toxicity during rectal chemoradiotherapy
Mean pelvic marrow dose above approximately 24 Gy and V40 above 13% identified higher hematologic toxicity risk during rectal chemoradiotherapy.
Deep learning reduced pediatric craniospinal target contouring from eight hours to 30 minutes
Automated pediatric CSI contours achieved a mean Dice score of 0.959 and reduced target-delineation time from approximately eight hours to 30 minutes.
Deformable registration substantially changed cumulative dose estimates in stereotactic re-irradiation
DIR reduced estimated liver maximum dose from 123.8 to 83.2 Gy, but accuracy deteriorated markedly for bowel and stomach.
Hybrid CT features predicted symptomatic pneumonitis after locally advanced NSCLC radiotherapy
A hybrid peri-tumoural CT model achieved an external AUC of 0.828 for predicting grade 2 or higher radiation pneumonitis.
An LLM agent generated head and neck IMRT plans comparable to clinical plans
Reference-free LLM planning improved hotspot control and boost-target conformity while maintaining organ-at-risk sparing comparable to clinical plans.