Eye tracking and imaging features predicted uncertainty in manual brain tumor contours
Behavioral and image-derived features explained 39% of interobserver contour uncertainty during manual brain tumor delineation.
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CHAF1A promotes DNA repair and tumor radioresistance through RAD51 and KU70
CHAF1A supported homologous recombination and non-homologous end joining, while its depletion increased radiosensitivity in xenograft models.
Heart dose rises during esophageal IMPT but adaptive replanning limits the increase
Mean heart dose increased during esophageal IMPT, while heart-dose–triggered replanning reduced the excess dose in patients requiring adaptation.
Chemoradiotherapy and immunoradiotherapy reshape distinct esophageal cancer microenvironment programs
Chemoradiotherapy suppressed LAMC2–macrophage signalling, while immunoradiotherapy enriched CCL5-positive CD8 T cells in preclinical esophageal squamous-cell carcinoma models.
Most European proton candidates still face critical access shortages
More than 56,000 theoretically eligible European patients lived in areas with no proton access or critical capacity shortages in 2025.
Interpretable AI separated three-year anal cancer relapse risk after chemoradiotherapy
An explainable model separated three-year local relapse rates of 11% versus 39%, but lacks independent external validation.
Danish head and neck risk model generalized to an Australian radiotherapy cohort
The model retained moderate discrimination for recurrence and metastasis, but predicted non-cancer death less reliably, especially in older patients.
Calling it “radiation therapy” reduced treatment preference compared with “radiotherapy”
In a randomized US survey, “radiation therapy” reduced selection of the same treatment by 8.3 percentage points versus “radiotherapy.”
Day-before-surgery radiotherapy matched diclofenac for heterotopic ossification prevention
A single 7 Gy fraction delivered 20–28 hours before hip arthroplasty produced similar heterotopic ossification rates to postoperative diclofenac.
Retroverted uterus altered cervical brachytherapy dosimetry without worsening disease control
Retroverted uterine position increased rectal and bowel dose during cervical brachytherapy, but survival, recurrence and severe toxicity remained comparable.
Simulation-free CBCT workflow enabled urgent radiotherapy within about two hours
The OSCAR workflow delivered the first urgent or palliative fraction without planning CT in approximately 1 hour 50 minutes.
Real-world brain MR-only implementation exposed frequent synthetic CT artifacts
Synthetic CT artifacts were common during brain MR-only implementation, highlighting workflow QA and patient-selection issues not captured by controlled validation.
Commercial AI synthetic CT showed good soft-tissue agreement but important high-density failures
AI synthetic CT preserved soft-tissue HU and geometry well, while bone, air interfaces and implanted devices remained important failure modes.
Radiotherapy-specific nutrition screening tool showed high agreement with established assessments
NRS-RT showed 92.9% sensitivity and 97.2% specificity versus NRS-2002, but requires external validation before clinical adoption.
Twenty-two Gy SRS was associated with better brain metastasis control than 20 Gy
Single-fraction 22 Gy SRS achieved higher one-year local control than 20 Gy, although retrospective dose selection creates important confounding.