CT–MRI fusion improved contrast-free lung perfusion mapping for radiotherapy planning
Multimodal CT–MRI perfusion maps matched SPECT better than single-modality methods and reduced high-function lung dose in exploratory planning.
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STAMP accelerated gynecologic brachytherapy planning without compromising dosimetry
The standardized workflow generated clinically comparable interstitial brachytherapy plans in a median of 10 minutes versus 28 minutes for manual planning.
SBRT controlled bone lesions but rarely delayed systemic therapy in bladder cancer
Two-year local control reached 88%, but median progression-free survival was 5.8 months and systemic treatment changed after 4.4 months.
Re-irradiation was associated with longer survival after pediatric diffuse midline glioma progression
COMPPARE enrolled 2,524 patients from 51 institutions in 52 months, with Black participation reaching 16% of the cohort.
Poor sleep and fatigue were common after head and neck radiotherapy
Poor sleep affected 69% of survivors, while 21.4% screened as high risk for obstructive sleep apnoea.
Omitted guideline-recommended sectors drove local failure after sacral SBRT
Seventy-three percent of failures after nonadherent sacral contouring involved sectors that guidelines recommended including in the clinical target volume.
RT-Optimus replaces maximum tolerated dose with an optimal combination regimen
Experts propose selecting radiotherapy–drug regimens using efficacy, scheduling, late toxicity, biomarkers, and patient-reported outcomes rather than maximum tolerated dose alone.
Patient-informed design supported rapid and representative COMPPARE trial accrual
COMPPARE enrolled 2,524 patients from 51 institutions in 52 months, with Black participation reaching 16% of the cohort.
Online proton adaptation improved dosimetry but required about one hour per fraction
Adaptation would have improved organ sparing or target coverage in 46% of fractions, with a median workflow time of 61.9 minutes.
Carbon-ion Gy(RBE) values are not directly interchangeable between planning systems
Different carbon-ion RBE models can assign substantially different biological doses to the same absorbed-dose distribution, requiring context-specific translation.
Submillimetre MLC errors substantially altered HyperArc brain metastasis dose
A 1 mm symmetric MLC closing reduced minimum GTV dose by 25%, while translations caused cumulative target undercoverage.
High-density bolus provided accurate superficial photon dose when air gaps were minimized
A 1 cm high-density bolus overcame 6 MV photon build-up, but a 2 cm air gap reduced small-field skin dose by 21%.
TLD-100 response varied systematically with synchrotron proton dose rate
TLD-100 over-responded below 7 Gy/s and under-responded above 300 Gy/s, despite remaining dose-independent from 3 to 18 Gy.
T1-weighted MRI plus CT best automated EPTN neuro-oncology organ contouring
A dual-input MRI–CT model segmented 25 neurological organs with a median Dice score of 0.80 and surface Dice of 0.84.
Pelvic insufficiency fractures affected nearly one-third after gynecologic IMRT
Pelvic insufficiency fractures occurred in 29.2% of patients, with postmenopause and elevated baseline t-PINP independently predicting risk.