Sleep adjustment avoided sedation in most pediatric radiotherapy fractions
A structured sleep protocol enabled sedation-free delivery in 96.4% of radiotherapy fractions among children younger than four years.
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Metabolic tumour volume refined treatment selection in early NK/T-cell lymphom
An MTV threshold of 50 mL identified patients with poorer survival who appeared to benefit from combined-modality treatment.
Protons produced greater subclinical lung changes after breast nodal irradiation
Proton therapy produced greater CT-detected lung changes than photons despite lower lung dose and no increase in clinical pulmonary toxicity.
Bladder dose escalation reduced invasive recurrence without increasing toxicity
Two-year invasive recurrence fell from 27.5% to 5.5% with dose escalation, without higher grade 2 or greater toxicity.
Experts reached limited consensus on prostate GTV contouring and micro-boosting
Only 33% of statements reached consensus, but experts agreed on multimodality imaging, eligible lesions, and daily image guidance.
Earlier lung cancer diagnosis exposed major delays in curative radiotherapy access
In 2024, only 3.2% of English patients began curative radiotherapy within the 49-day target despite rapidly rising demand.
High-dose chemotherapy was linked to radiographic brain injury after proton therapy for medulloblastoma
Radiographic brain injury occurred in 16% of children, all asymptomatic; every affected patient had received high-dose chemotherapy.
Children’s Oncology Group guidelines standardize pediatric radiotherapy simulation across treatment sites and techniques
COG guidelines standardize pediatric radiotherapy simulation across treatment sites and techniques
Fifteen years of radiotherapy data were converted into an AI-ready resource
An open-source workflow structured 15 years of radiotherapy data, although reirradiation prediction showed only modest discrimination.
Dose-guided positioning optimized proton target coverage within three minutes
Automated dose-guided positioning matched anatomical alignment overall and improved primary target coverage by 1.0% when the clinical goal was initially missed.
Transformer dose engine achieved near-Monte Carlo accuracy for carbon ion therapy
The Transformer calculated carbon-ion pencil-beam doses in 14 milliseconds with 98.0% gamma agreement at stringent 1%/1 mm criteria.
Tetrandrine trial will test prevention of lung injury during esophageal chemoradiotherapy
A randomized phase II trial will test whether intravenous tetrandrine reduces grade 2 or higher lung injury from 25% to 10%.
FLASH altered early molecular responses without improving breast cell survival
Electron FLASH changed DNA-damage, transcriptomic, cytokine, and microtubule responses but did not alter clonogenic survival under normoxic conditions.
NanOx incompletely predicted laryngeal cancer cell survival across a helium Bragg peak
NanOx predictions differed from measured laryngeal cancer cell survival by 20–37% and overestimated the distal biological gradient.
Experts prioritized biomarker-guided radiotherapy–systemic therapy trials in head and neck cancer
International experts identified eight research priorities covering biomarker-guided chemoradiation, immunotherapy sequencing, and consolidation radiotherapy in metastatic head and neck cancer.