Radiotherapy may help prime immunotherapy in biologically distinct acral melanoma
Acral melanoma has an immune-cold phenotype and weaker ICI responsiveness; radiotherapy-based immune priming is biologically plausible but clinically unproven.
Latest research
Search the archiveMemory-network avoidance PCI was feasible beyond hippocampal sparing in limited-stage SCLC
VMAT-based PCI spared additional memory-network structures while maintaining whole-brain coverage in two patients with limited-stage SCLC.
Atrial fibrillation affected 7.6% after thoracic radiotherapy in pooled analysis
Reported atrial fibrillation occurred in 7.6% after thoracic radiotherapy when cohorts with substantial perioperative confounding were excluded.
Personalized ctDNA predicted outcomes throughout treatment for localized soft tissue sarcoma
Personalized ctDNA was detected in 85% at baseline and remained independently prognostic before treatment, after radiotherapy and after surgery.
HYPOCON tests biphasic chemoradiotherapy to target hypoxia in head and neck cancer
HYPOCON will test 40 Gy/20 fractions followed by 15 Gy/3 against 55 Gy/20, both with concurrent cisplatin.
Cystic vestibular schwannomas shrank earlier after SRS than solid tumors
Large cystic Koos III–IV vestibular schwannomas showed greater early shrinkage after SRS, with 100% local control in 15 cystic cases.
ASTRO 2026 Preview. SBRT in Metastatic Ewing Sarcoma: AEWS1221 and the Gap Between Local Control and Deliverability
AEWS1221 was the first Children's Oncology Group trial to evaluate SBRT, introduced to make treatment of every metastatic site achievable. Preliminary data suggest it reached a minority of eligible patients. That, rather than the local control rate, is the finding that matters.
Single-arc VMAT remained comparable to double-arc planning with bilateral hip prostheses
Double-arc VMAT was slightly more robust, but single-arc planning achieved clinically comparable dosimetry with simulated bilateral hip prostheses.
SBRT timing relative to chemotherapy did not affect survival in stage I SCLC
Stage I SCLC survival was similar whether SBRT preceded chemotherapy or was delivered after chemotherapy had started.
All-in-one emergency radiotherapy delivered treatment in a median 25 minutes
An integrated CT-linac workflow delivered emergency radiotherapy in 24.7 minutes, with symptom relief in nearly 90% of patients.
Higher radiotherapy dose tracked with greater pathological response in neoadjuvant esophageal chemoradiotherapy
Each 10-Gy increase in biologically effective dose was associated with 39% higher odds of pathological complete response in esophageal squamous cell carcinoma.
DEGRO updates radiotherapy recommendations for Merkel cell carcinoma
DEGRO supports postoperative radiotherapy within eight weeks while expanding hypofractionated options for frail and selected Merkel cell carcinoma patients.
Advanced extranodal extension improved N3 risk identification in nasopharyngeal carcinoma
Adding advanced extranodal extension to N3 modestly improved prognostic discrimination and identified patients with substantially greater distant failure risk.
Jaw-partitioned VMAT increased peak-to-valley dose separation in spatially fractionated radiotherapy
Jaw-partitioned VMAT improved dose gradients and peak-to-valley separation in GRID and lattice plans, but approximately doubled monitor units.
Tumor-spread modeling enabled anisotropic glioblastoma treatment planning beyond MRI-visible disease
Model-predicted microscopic glioblastoma spread could be incorporated into clinically deliverable plans, but dose-painting accuracy deteriorated as target complexity increased.