Twenty-fraction cervical chemoradiation shortened treatment but raised a late GI toxicity signal
44 Gy in 20 fractions shortened cervical cancer treatment by seven days but showed numerically more severe late GI toxicity.
Latest research
Search the archiveSpectral CT could strengthen RT planning and adaptation, but clinical validation still lags
Spectral CT adds quantitative tissue information across planning, particle range estimation and adaptive imaging, but prospective outcome evidence remains limited.
Respiratory traces predicted treatment-day heart dose drift during post-mastectomy DIBH VMAT
Routine DIBH respiratory traces predicted fraction-level mean heart dose deviation, but LAD dose estimates were substantially less reliable.
Unilateral RT produced no contralateral neck failures in N2b oropharyngeal cancer
No contralateral neck recurrences occurred among 43 N2b patients receiving unilateral RT despite frequent high ipsilateral nodal burden.
MRI-derived oxygen extraction fell progressively during prostate MR-guided SBRT
Relative oxygen extraction declined across irradiated prostate and tumor tissue during five-fraction MRgSBRT, with the largest early changes.
Single-fraction SBRT has strongest curative evidence in peripheral lung and kidney tumors
ESTRO’s review supports selected single-fraction SBRT applications while highlighting major evidence and toxicity gaps in abdominal tumors.
FDG PET/CT improved nodal contour reproducibility over MRI in stage II–III breast cancer
Semi-automated FDG PET/CT produced more reproducible nodal target volumes than manual MRI and identified all metastatic nodes consistently.
SMART achieved durable local control in pancreatic cancer while distant progression dominated
After 50 Gy in five fractions, local progression was 15% at one year, while distant progression remained the dominant failure pattern.
Higher SMAD4 expression tracked with fewer distant failures after resected pancreatic cancer
Higher tumor SMAD4 was associated with better disease-free survival and lower distant metastatic risk after resection and adjuvant chemoradiotherapy.
Carbon-ion radiotherapy achieved 91% two-year local control in limited-stage SCLC
In 39 patients, carbon-ion RT achieved 91.2% two-year local control without grade ≥3 acute radiation-associated toxicity.
Repeated TURP predicted late urinary toxicity more strongly than focal prostate dose escalation
After prior TURP, focal SIB was not significantly associated with severe late GU toxicity, while repeated TURP consistently identified higher-risk patients.
Prostate motion during online adaptation supports routine verification before treatment
Across 1,378 adaptive fractions, 4.6% had shifts above 6 mm and longer adaptation times were linked to greater prostate displacement.
Deep-learning metal artifact reduction achieved sub-3% dose errors in head-and-neck radiotherapy
Retrospective DL-MAR studies achieved dose errors below 3%, but no prospective clinical validation has yet been reported.
EPTN marks a decade of European particle therapy collaboration and sets its next priorities
After 10 years, EPTN is shifting its focus toward prospective registries, adaptive therapy, harmonised QA and stronger clinical evidence.
Salvage HDR brachytherapy delayed systemic therapy after isolated seminal vesicle recurrence
In 22 patients, salvage HDR brachytherapy produced 40.5% five-year relapse-free survival but 18% developed grade ≥3 GU toxicity.