Anatomy-based traffic lights missed important dose changes during lung radiotherapy
In 604 fractions, traffic-light alerts partially identified target undercoverage but were unreliable proxies for organ-at-risk dose changes.
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S100A8/A9 blockade improved survival after abdominal irradiation in mice
Paquinimod blockade of S100A8/A9 improved survival, intestinal regeneration and barrier recovery after abdominal irradiation in preclinical models.
International survey identifies culture and leadership as central radiation oncology retention drivers
Across 53 countries, workforce retention was shaped by culture, leadership, career development, resource strain, recognition and burnout.
Proton use reached nearly 40% in recent Children’s Oncology Group radiotherapy trials
Across 27 years of COG trials, IMRT/VMAT replaced 3D photons while proton use expanded to nearly 40% of radiotherapy patients.
Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.
PTCOG review maps emerging roles for particle therapy in gynecologic cancers
Carbon ions show the strongest signal in radioresistant gynecologic tumors, while proton evidence centers on adjuvant treatment and reirradiation.
Minibeam radiotherapy achieved 92% one-year local control in refractory superficial tumors
In the first clinical minibeam series, 86% had symptomatic improvement and one-year local control reached 92% with minibeam treatment alone.
Progesterone exposure was associated with visual deficits in women with meningioma
Unopposed progesterone use was associated with eightfold higher odds of tumor-related visual deficit among women referred for meningioma radiotherapy.
No tested head phantom fully met cranial synthetic CT QA criteria
Skull-equivalent anatomy improved synthetic CT performance, but none of ten tested head phantoms satisfied all geometric, HU and dosimetric criteria.
SMART planning reduced memory-circuit dose during SRS for ≥10 brain metastases
SMART reduced mean memory-circuit dose from 2.9 to 1.8 Gy while maintaining greater than 95% target coverage.
Esophageal radiosensitization has many molecular targets but little practice-ready clinical evidence
A broad 6R-based review identifies numerous radiosensitization targets, but most remain preclinical and evidence is heavily concentrated in squamous-cell carcinoma.
Treatment satisfaction remained 85% at ten years after prostate LDR brachytherapy
At ten years after prostate LDR brachytherapy, 85% of respondents remained satisfied, while bowel quality of life remained independently associated with satisfaction.
Brain metastasis SRS fractionation varied widely across Turkish radiation oncologists
Tumor volume and OAR proximity drove brain metastasis fractionation, while preoperative SRS showed a substantial preference-to-practice gap.
DWI/ADC changed residual cervical tumor geometry before brachytherapy despite similar overall volumes
Adding DWI/ADC produced substantially different residual GTV geometry before cervical brachytherapy, with a median Dice overlap of only 0.33.
Patients with documented fatigue were less likely to complete electronic symptom surveys after breast RT
Patients with clinician-documented fatigue had 39% lower odds of completing electronic fatigue assessments, exposing an important limitation of PRO-only monitoring.