Severe brainstem necrosis followed standard proton CSI in 22q11.2 deletion syndrome
A patient with 22q11.2 deletion developed refractory brainstem necrosis nine months after guideline-concordant proton craniospinal irradiation.
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Structured cumulative-dose review triggered replanning in one-quarter of proton reirradiation cases
Voxel-wise cumulative EQD2 review prompted reoptimization in 25.5% of proton reirradiation courses and exposed frequent registration problems.
Modern proton breast radiotherapy offers cardiopulmonary sparing but randomized clinical benefit remains pending
Modern proton techniques reduce cardiopulmonary dose and can control skin exposure, while randomized cardiac and cancer-control endpoints remain pending.
Iodine-125 brachytherapy preserved lung function in high-risk NSCLC patients
CT-guided iodine-125 implantation achieved 60.7% one-year response without grade ≥3 pneumonitis in patients with severe pulmonary dysfunction.
Immune-rich rectal tumors responded better to neoadjuvant radiotherapy than stromal-rich tumors
Responsive rectal tumors showed greater cytotoxic immune infiltration, while poor responders were enriched for stromal, EMT and oncogenic pathways.
Food insecurity predicted markedly worse survival after comprehensive breast nodal irradiation
Five-year survival was 74.9% versus 90.2% for patients living in food-insecure versus other areas despite similar cancer treatment.
Radiomic shape features improved xerostomia prediction after nasopharyngeal radiotherapy
Adding parotid–target overlap shape features improved moderate-to-severe xerostomia prediction from AUC 0.66 to 0.78.
Multimodal AI proposed major surveillance reduction after stage II NPC
External validation achieved AUC 0.986, while modeled risk-adapted surveillance reduced visits by 90.0–98.5% and identified every observed failure.
Higher tumor LET predicted better local control after carbon-ion NPC reirradiation
Recurrent NPC with GTV LETd99 ≥39.4 keV/μm had 94.4% versus 65.3% two-year local control after carbon-ion reirradiation.
Antiscatter grid sharply improved proton CBCT accuracy and soft-tissue contrast
A 2D antiscatter grid reduced soft-tissue CT-number error from 169 to 38 HU at unchanged imaging dose.
Three-cycle thoracic Quad Shot was feasible with concurrent systemic therapy in metastatic NSCLC
Three Quad Shot cycles caused limited high-grade toxicity, no systemic-therapy delays and frequent thoracic symptom improvement.
Clinical-genomic models improved prediction of late breast radiotherapy toxicity
Adding SNP data increased arm-lymphedema prediction AUC from 0.78 to 0.93 in the multicenter REQUITE cohort.
Mechanistic model predicted six-month lymphocyte depletion after lung SBRT
A circulation-based model predicted post-SBRT lymphocyte trajectories and linked a higher predicted lymphocyte nadir with better survival.
Daily skin variation caused substantial target underdose in kidney proton SABR
Daily surface changes shifted proton beam depth by up to 17.4 mm and reduced accumulated target D99 by up to 24.3%.
Radiotherapy achieved 98% local control in head and neck paragangliomas
Protons, SRS and IMRT produced 98% overall local control without grade 3–5 toxicity in 54 paragangliomas.