Computed tomography radiomics showed exploratory recurrence signals in mandibular osteoradionecrosis
In 24 surgically confirmed cases, three radiomic features differed nominally between pure osteoradionecrosis and osteoradionecrosis with recurrence.
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Intrafractional motion frequently exceeded tolerance during multi-target stereotactic radiosurgery
After 66% of couch-angle changes, motion exceeded tolerance, and 0.5-millimetre and 0.5-degree errors reduced near-minimum target dose by 7.6%.
High lactate dehydrogenase-5 and low lymphocyte infiltration identified higher relapse risk after prostate radiotherapy
Combined high lactate dehydrogenase-5 expression and low tumor-infiltrating lymphocyte density independently identified higher biochemical relapse risk after prostate radiotherapy.
Pan-mucosal irradiation did not improve outcomes in head and neck unknown primary cancer
Adding pan-mucosal irradiation did not improve survival or reduce mucosal recurrence compared with nodal-only irradiation in thoroughly staged head and neck unknown primary cancer.
Automated volumetric modulated arc therapy planning improved organ-at-risk sparing in head and neck radiotherapy
Across 500 clinical cases, automated planning preserved target coverage and was associated with lower doses to multiple critical structures than earlier manual planning.
First-line temozolomide and radiotherapy produced similar survival in high-risk low-grade glioma
After 13 years, first-line temozolomide and radiotherapy produced similar progression-free and overall survival across molecularly classified low-grade gliomas.
Severe late toxicity was generally uncommon after prostate radiotherapy in REQUITE
Across 1,760 patients, most grade 3 adverse events remained below 1.5%, although post-prostatectomy urinary incontinence reached 10.2% by eight years.
Percussive ventilation enabled imaging and lung stereotactic ablative radiotherapy within one breath-hold
Three of four patients completed final imaging and lung stereotactic ablative radiotherapy within one assisted breath-hold, with only grade 1 adverse events.
Hypofractionated proton reirradiation showed similar survival to photons in recurrent glioblastoma
Median survival was 8.3 months after proton reirradiation, with 5.6% grade 3–4 radiation necrosis and no survival difference versus photons.
Respiratory motion remained small during postoperative whole-breast radiotherapy.
Mean breast target displacement was below 1.3 mm in every direction, with calculated respiratory margins of approximately 1 mm.
Higher left anterior descending coronary artery dose was associated with cardiac events after breast radiotherapy
A maximum left anterior descending coronary artery dose of at least 12 Gy was independently associated with higher long-term cardiac risk.
Conventional fractionation substantially reduced gastrointestinal motility–driven interplay in pancreatic proton therapy.
Gastrointestinal motility reduced single-fraction target coverage and broadened organ-at-risk dose ranges, while conventional fractionation substantially attenuated the interplay effect.
Proton therapy timing was not independently associated with worse rhabdomyosarcoma outcomes
Four-year overall survival was 81.2%, and starting proton therapy at week 14 or later was not independently associated with worse outcomes.
Multimodal respiratory tracking enabled real-time voxel-wise anatomical reconstruction during radiotherapy
The patient-specific framework outperformed three comparison methods and reconstructed respiratory anatomy in 15.6 milliseconds per frame.
Electromagnetic tracking enabled sub-5-mm magnetic resonance imaging–ultrasound guidance in gynecologic brachytherapy
Live magnetic resonance imaging–ultrasound fusion achieved under 4 mm registration accuracy and under 5 mm needle localization in two clinical implants.