Carbon ions produced more persistent tumor damage but hypoxic cells showed late rebound
Carbon ions prolonged tumor-cell damage while chronic hypoxia supported late proliferative and macrophage rebound in rat prostate tumors.
Latest
Non-endemic nasopharyngeal cancer showed similar locoregional and distant failure rates
Five-year overall survival was 71%, with most distant failures occurring during the first three years after treatment.
VMAT-based pediatric TBI achieved organ sparing with acceptable early clinical outcomes
VMAT-TBI achieved 96.6% mean PTV D95 while keeping mean lung and kidney doses below 9 Gy.
Early PSA-density kinetics after prostate SABR identified patients at high recurrence risk
Combining ISUP grade with 3–6-month PSA-density kinetics separated seven-year biochemical control at 93.5% versus 53.4% after SABR without ADT.
Severe pneumonitis developed after carbon-ion RT following nivolumab in lung cancer
Life-threatening bilateral pneumonitis with concurrent Pneumocystis infection developed three days after carbon-ion RT in a patient previously treated with nivolumab.
Extensive coronary calcification on breast RT planning CT predicted ischemic heart disease
All six ischemic events occurred in patients with extensive coronary calcification on breast RT simulation CT, versus none with absent or mild calcification.
Breathing-phase targeting reduced normal-tissue dose in proton lung radiotherapy
Planning on selected respiratory phases reduced lung, heart and esophageal dose, but the optimal phase differed by toxicity endpoint.
ELCC 2026 highlights expanding roles for radiotherapy across modern thoracic oncology
ELCC 2026 highlighted growing integration of SBRT and thoracic radiotherapy with targeted therapy, immunotherapy and biomarker-guided treatment selection.
Modern radiotherapy shifted the accuracy problem from dose calibration to spatial dose delivery
Modern dosimetry can meet historical accuracy requirements, but tighter geometric precision and particle-specific uncertainties increasingly determine treatment accuracy.
Induction TPF did not improve three-year PFS over adjuvant PF in locally advanced NPC
Three-year PFS was 79.0% with induction TPF versus 74.5% with adjuvant PF, with substantially different toxicity profiles.
Particle therapy suppressed aggressive breast cancer behavior beyond clonogenic cell killing
Protons, helium and carbon ions suppressed migration and invasion that increased after photon irradiation, with helium showing a favorable biological-dosimetric balance.
Updated level IVa contouring reduced predicted hypothyroidism risk in nasopharyngeal cancer
Updated level IVa delineation reduced predicted hypothyroidism from 43.9% to 34.9% without compromising target coverage.
FES PET changed nodal staging, field design and boost dose in ER-positive breast cancer
In a diagnostically difficult breast cancer case, FES PET identified occult ER-positive nodal disease and materially changed radiotherapy volume and dose.
Fat saturation destabilized most MRI radiomics features used for radionecrosis prediction
Only 10.7% of T2 MRI radiomics features remained highly stable across fat-saturation protocols, and stability filtering improved prediction.
Submandibular gland transfer reduced salivary-gland dose by 12 Gy during proton therapy
Surgical transfer reduced contralateral submandibular mean dose by approximately 12 Gy during bilateral IMPT without compromising target coverage.