Tissue heterogeneity substantially alters absorbed dose in intraoperative radiotherapy
Absorbed dose near the applicator varied markedly by tissue composition despite accurate Monte Carlo calculation by the treatment planning system.
Latest
Mid-treatment tumour shrinkage predicted survival in oropharyngeal cancer
Tumour volume reduction above 40% during radiotherapy was independently associated with improved overall survival in patients with oropharyngeal cancer.
Preoperative radiotherapy did not worsen renal function after retroperitoneal sarcoma surgery
Preoperative radiotherapy was not associated with greater renal dysfunction after nephrectomy for retroperitoneal sarcoma during follow-up extending to 80 months.
ESTRO–ASTRO guidance standardises reirradiation for locally recurrent rectal cancer
ESTRO–ASTRO guidance supports selected rectal cancer reirradiation using 30–40 Gy regimens, cumulative dose assessment, inverse planning and daily volumetric imaging.
Early diffusion changes precede brain lesions after proton therapy for low-grade glioma
Regional diffusion changes distinguished patients who developed contrast-enhancing brain lesions as early as six months after proton therapy.
Body composition adds little to radiotherapy toxicity prediction
Computed tomography-derived muscle measures ranked highly for toxicity and quality of life, but added little predictive value beyond established clinical factors.
Medical debt after radiotherapy linked to insurance and neighborhood disadvantage
Commercial insurance, current smoking, single status, and neighborhood disadvantage were independently associated with radiotherapy-related debt sent to collections.
End-to-end test achieved high dosimetric agreement across adaptive platforms
A reusable phantom-based test verified simulation-omitted adaptive workflows on cone-beam computed tomography-guided and magnetic resonance-guided treatment systems.
Induction chemotherapy benefit varied by cervical cancer risk and treatment density
Induction chemotherapy showed no overall survival benefit, with outcomes differing by disease risk and the intensity of pre-radiotherapy treatment.
Combined dose and linear energy transfer predict local control after carbon-ion radiotherapy
High-dose, high-linear-energy-transfer target coverage stratified local control after carbon-ion radiotherapy for adenoid cystic carcinoma.
Radiotherapy primes PDL1-targeted radionuclide therapy but splenic uptake limits efficacy
Radiotherapy increased tumor uptake of PDL1-targeted radionuclide therapy, while antibody co-dosing reduced splenic trapping and restored antitumor efficacy in mice.
Convergent 60 keV photons show cell-dependent biological effectiveness
Convergent 60 keV photons matched orthovoltage radiation and showed comparable or greater biological effectiveness than 6 MV photons, depending on cell type.
CyberKnife reduced low-dose exposure in left-sided partial-breast irradiation
CyberKnife improved conformity and reduced cardiac, pulmonary, and low-dose exposure, while noncoplanar linac techniques remained clinically acceptable alternatives.
Cosmesis reporting after radiotherapy for non-melanoma skin cancer remains inconsistent
Most studies used heterogeneous, poorly reproducible cosmetic assessment methods, limiting comparisons between radiotherapy techniques and supporting development of a validated standard.
Knowledge-based prostate planning transfers across fractionation regimens with comparable plan quality
A conventional-fractionation model produced clinically acceptable moderately hypofractionated prostate plans, with comparable overall quality and slightly reduced target homogeneity.