Commercial lung phantom density errors can reduce target coverage by 3%
Lot-to-lot density variation in lung-equivalent inserts reduced planning target volume coverage by up to 3%, exceeding the stated clinical tolerance.
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Low monitor unit deliveries show pulse-limited variability on a modern linear accelerator
Discrete pulse counts limited fractional monitor unit precision, particularly for high-dose-per-pulse flattening filter-free beams.
Ultrahigh dose-rate protons reduce hydrogen peroxide yield in water
Hydrogen peroxide production decreased as proton dose rate increased, with Geant4-DNA simulations reproducing the oxygen-dependent experimental trend.
Monocular surface imaging enables real-time breast dose reconstruction
Patient-specific surface imaging reconstructed breast radiotherapy dose with a 93.8% gamma passing rate and 42-millisecond latency without additional imaging radiation.
Reference beam data may streamline commissioning but cannot replace local validation
Reference datasets can support linear accelerator beam modelling, but machine-specific measurements remain essential for small fields, complex delivery, and long-term verification.
Neutron background limits prompt-gamma range verification in carbon-ion therapy
Prompt-gamma profiles tracked beam range, but stronger neutron backgrounds reduced retrieval precision for carbon ions under clinically relevant conditions.
Machine-specific timing model improves synchrotron proton spot delivery prediction
Measured multi-energy extraction characteristics enabled accurate delivery-time prediction across 605 clinical proton fields, supporting more reliable interplay simulations.
Dose de-escalation improved patient-reported outcomes in early p16-positive oropharyngeal cancer
Reducing radiotherapy from 70 Gy to 60 Gy was associated with better one-year swallowing outcomes and lower acute toxicity in selected patients.
Prolonged pembrolizumab was associated with longer survival after chemoradiation in non-small cell lung cancer
Longer pembrolizumab exposure after chemoradiation was associated with lower mortality, but immortal time bias prevents causal interpretation.
Explainable machine learning predicts structure-specific quality assurance performance in intensity-modulated radiotherapy
Anatomy- and dose-based machine learning predicted gamma passing rates accurately for organs at risk, but less reliably for target volumes.
Single-fraction ultrahigh dose-rate proton therapy showed early safety in thoracic metastases
Single-fraction proton treatment produced pain responses without grade 2 or higher related toxicity in 10 patients with thoracic bone metastases.
Glutathione S-transferase mu 3 limits testicular injury after ultrahigh dose-rate irradiation
In mice, ultrahigh dose-rate X-rays caused less early testicular damage than conventional irradiation, with protection linked to ferroptosis suppression.
Ultrahigh dose-rate radiotherapy still requires conformal planning and conservative dose constraints
Normal-tissue sparing with ultrahigh dose-rate radiotherapy remains conditional and cannot replace conformal dosimetry, organ-at-risk constraints, or rigorous quality assurance.
Dual-scan conformal cone-beam computed tomography improves target-region image quality
Dynamic collimation improved target-region contrast and signal-to-noise ratio while preserving full-field information without increasing the total photon budget.
Vaginal cuff brachytherapy boost was associated with improved survival in stage II endometrial cancer
Adding vaginal cuff brachytherapy to whole pelvis radiation therapy was associated with improved overall survival in stage II endometrioid endometrial cancer.