High-dose prednisone produced transient symptom improvement in radiation-associated lower cranial neuropathy
Prednisone 3 mg/kg improved symptoms in 3 of 5 survivors with late cranial neuropathy, but the benefit disappeared by 6–10 weeks.
Tag
late-effects
COG highlights major gaps in radiation care for adolescents and young adults
AYA patients face distinct radiation-related late effects and psychosocial challenges, yet age-specific dose constraints and prospective outcome data remain scarce.
Late chest-wall pain affected one-third of patients after breast radiotherapy
Across 5,509 evaluable patients, 34% developed late chest-wall pain, although definitions and reported risk factors varied substantially.
Trismus persisted in 35% of head and neck cancer survivors 10 years after radiotherapy
Ten years after radiotherapy, 35% of long-term head and neck cancer survivors had trismus with persistently worse quality of life.
Low incidental brain doses were not linked to early cognitive decline after head and neck radiotherapy
Regional brain dose showed no significant association with cognition through 12 months, although only 24 patients completed one-year testing.
Prostate radiotherapy modestly increased secondary pelvic cancer incidence over long follow-up
Randomized evidence suggested a 4.5-point increase in second-cancer incidence, while excess mortality from other cancers was substantially smaller.
Pelvic radiotherapy was associated with modest excess secondary uterine cancer risk
Twenty-year secondary uterine cancer incidence increased after pelvic radiotherapy, but absolute excess risk remained below two percentage points.
Severe late toxicity was generally uncommon after prostate radiotherapy in REQUITE
Across 1,760 patients, most grade 3 adverse events remained below 1.5%, although post-prostatectomy urinary incontinence reached 10.2% by eight years.