ctDNA clearance after palliative RT tracked longer survival in advanced melanoma
One-year survival was 83% after ctDNA clearance versus 21% when ctDNA increased after RT during immune checkpoint inhibition.
Tag
melanoma
Radiotherapy may help prime immunotherapy in biologically distinct acral melanoma
Acral melanoma has an immune-cold phenotype and weaker ICI responsiveness; radiotherapy-based immune priming is biologically plausible but clinically unproven.
Adjuvant radiotherapy added no survival benefit in modern melanoma treatment
Adjuvant radiotherapy did not improve recurrence-free or overall survival, but concurrent systemic therapy did not increase radiotherapy-related toxicity.